Receptors zonal expression

Ressler K.J., Sullivan S.L. and Buck L. (1993). Zonal organisation of odorant receptor gene expression in the olfactory epithelium. Cell 73, 597-609. 

Odor discrimination could involve a very large number of different odorant receptors, each specific for one or a small set of odorants 818 The information generated by hundreds of different receptor types must be organized to achieve a high level of olfactory discrimination 820 Zonal expression of olfactory receptors 821 Convergence of sensory neurons onto a few glomeruli in the olfactory bulb 821... 

Ressler KJ, Sullivan SL, Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium.Cell 73(3) 597-609 Ressler KJ, Sullivan SL, Buck LB (1994) Information coding in the olfactory system evidence for a stereotyped and highly organized epitope map in the olfactory bulb.Cell 79(7) 12451255... 

Qasba P. and Reed R. (1998). Tissue and zonal-specific expression of an olfactory receptor transgene. J Neurosci 18, 227-236. 

A major drawback of many studies of the chemical neuroanatomy is that they were conducted in only one species, the rat. There is extensive evidence for species differences in the distribution of the synthetizing enzyme of acetylcholine (ChAT), muscarinic cholinergic receptors and acetylcholinesterase (see Section 3.10.), and there is reason to assume that a similar interspecies variability exists for other transmitter systems. The expression of Zebrin by certain subpopulations of Purkinje cells, and the zonal patterns in the distribution of 5 -nucleotidase, only occur in certain species. It is a fortunate coincidence for the experimental neuroscientist that the Zebrin zonal pattern is expressed in rats, but in other species like the cat or macaque monkeys all Purkinje cells are Zebrin-immunoreactive. Many species-differences in the chemical neuroanatomy of the cerebellum may be due to the selectivity of the antibodies employed in the im-munocytochemical techniques, but other differences may be real and may reflect true variations in structure or in the transmission and second messenger systems of the cerebellum. 

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