Receptors, genetic

DeRijk R, de Kloet ER. (2005) Corticosteroid receptor genetic polymorphisms and stress responsivity. Endocrine. 28, 263-270. 

Swanson HI, Bradfield CA. 1993. The Ah receptor Genetics, structure and function. Pharmacogenetics 3 213-230. 

Suboptimal platelet response to clopidogrel may be due to an increased number of platelet P2Y 2 receptors or polymorphism of platelet receptors. Genetic polymorphisms of platelet GPIIb/llla, GPIa/lla, or P2Y 2 receptors have been reported to affect platelet function and may influence dopidogrel response variability (103-105). Recently, it was reported that an increased percentage of patients with peripheral arterial disease have the P2Y 2 receptor H2 haplotype (104). However, in another study, the relation of this haplotype to clopidogrel responsiveness could not be demonstrated (105). Since the relation... 

More than 17,000 citations for genetic studies of receptors and 8074 citations for receptor polymorphisms were found for 1975-2003 (Table 1). The fraction of human receptor genetic citations relative to citations for all species has risen steadily from about half (363/694 = 0.52) in 1986-1988 to about two-thirds (3605/5342 = 0.67) currently (2001-2003). The fraction of citations that deals with human receptor polymorphisms stood at about three-fourths those for all species in the mid-1980s (170/229 = 0.74), but now includes more than 90% that for all studies. The number of human receptor polymorphism citations has increased more than 16-fold (2753/170= 16.2) during the same interval (1986-2003) (Table 2). 

Table 1 Medline Literature Citations on Receptor Genetics and Receptor Polymorphisms Inclusive of 1975-2003...

Cool DR, Normant E, Shen F, Chen HC, Pannell L, Zhang Y, Loh YP. Carboxypeptidase E is a regulated secretory pathway sorting receptor genetic obliteration leads to endocrine disorders in Cpe(fat) mice. Cell 1997 88 73-83. 

Dmitriev I, Kashentseva E, Rogers BE, Krasnykh V, Curiel DT. 2000. Ecto-domain of coxsackievirus and adenovirus receptor genetically fused to epidermal growth factor mediates adenovirus targeting to epidermal growth factor receptorpositive cells. J. Virol. 74 6875-84... 

Zhang JP, Lencz T, Malhotra AK (2010) D2 receptor genetic variation and clinical response to antipsychotic drug treatment a metaanalysis. Am J Psychiatry 167 763-772... 

He, P., Court, M.H., Greenblatt, D.J. and von Molfke, L.L. (2006) Human pregnane X receptor genetic polymorphisms, alternative mRNA splice variants, and cytochrome P450 3A metabolic activity. Journal of Clinical Pharmacology, 46, 1356-1369. 

Signaling by ErbB-3 and ErbB-4 inflicts an additional level of complexity by applying a wide but shared variety of direct ligands to both receptors. Genetic evidence implies that signaling by neuregulins is essential for epithelial organs, for effectors of the nervous system such as Schwann cells and neu-... 

---