Receptor Tetanus neurotoxin

Tetanus neurotoxin-insensitive VAMP Tosyl-lysyl chloromethyl ketone Toll-like receptor... 

LaUi G, Bohnert S, Deinhardt K, Verastegui C, Schiavo G (2003) The journey of tetanus and botulinum neurotoxins in neurons. Trends Microbiol 11 431-7 Lambeau G, Lazdunski M (1999) Receptors for a growing family of secreted phospholipases A2. Trends Pharmacol Sd 20 162-70... 

Future important discoveries will be the identification of the neuron-specific receptors of CNTs and of the mode of internalization and membrane translocation of the neurotoxins. Another important line of research is aimed at finding specific inhibitors of these metallo-proteinases. Inhibitors which can cross the neuronal plasmalemma into the cytosol would be potential therapeutic agents in the treatment of tetanus and botulism. The modification of BoNTs to prolong their life time inside the NMJs would be an important research goal to improve the treatment of dystonias. The determination of the three-dimensional structure of these neurotoxins will greatly accelerate the research on these fronts. 

Middlebrook JL. (1989) Cell surface receptors for protein toxins. In Botulinum neurotoxin and tetanus toxin ( Simpson LL, ed) San Diego Academic Press. 

Middlebrook, J.L., Cell surface receptors for protein toxins, m Botulinum Neurotoxins and Tetanus Toxin, Simpson, L.L., Ed., Academic Press, New York, 1989, chap. 5. 

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