Receptor maitotoxin

Biochemical site of action Site 1 on voltage-dependent sodium channel Site 5 on voltage-dependent sodium channel Catalytic subunit of phosphorylase phosphatases Kainate receptor in central nervous system Unknown Ciguatoxin site 5 on voltage-dependent sodium channel Maitotoxin calcium channels... 

Physiologic effect Inhibition of ion conductance Repetitive firing, shift of voltage dependence of activation Inhibition of phosphorylase phosphatases 1 and 2a Receptor-induced depolarization and excitation Unknown Ciguatoxin repetitive firing, shift of voltage dependence of activation Maitotoxin calcium ion influx... 

Brereton, H.M., Chen, J., Rychkov, G., Elarland, M.L., and Barritt, G.J. 2001). Maitotoxin activates an endogenous nonselective cation channel and is an effective initiator of the activation of the heterologously expressed hTRPC-1 (transient receptor potential) non-selective cation channel in H4-IIE liver cells. Biochem BiophysActa 1540, 107-126. 

Lundy, P.M., Nelson, P., Mi, L., Frew, R., Minaker, S., Vair, C., and Sawyer, T.W. 2004. Pharmacological differentiation of the P2X7 receptor and the maitotoxin-activated cationic channel. European Journal of Pharmacology 487,17—28. 

Schilling, W.P., Wasylyna, T, Dubyak, G.R., Humphreys, B.D., and Sinkins, W.G. 1999. Maitotoxin and P2Z/P2X(7) puriner-gic receptor stimulation activate a common cytolytic pore. Am J Physiol 277, C766-C776. 

Calcium channels that are activated by potential were thought to be the receptor of maitotoxin, but nonexcitable cells are also the target to this toxin. Although the mechanism of action of maitotoxin is not fully understood, a nonselective cation channel seems to be the effecter to maitotoxin. " Calcium influx has been also proposed as the main effect of polycavemoside. ... 

Musgrave, I.F., R. Seifert, and G. Schultz, Maitotoxin activates cation channels distinct from the receptor-activated non-selective cation channels of HL-60 cells. Biochem J, 1994 301 (Pt 2) 437-441. 

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