Receptor induced magnetization enhancement effect

This modified CR is targeted for blood. This modified CR designated as MS-325 exploits the relaxivity, r, the coefficient which relates the H20 T to the concentration of CR in vitro. The r of free MS-325 is 6.6 (mM) 1 S-1 but the value increases to SOSO (mM) 1 S 1 when the CR is bound to albumin. This means that the CR is reversibly activated on binding to human serum albumin and is very much more effective in reducing H20 T value. Hence the detection is made easy at much lower levels. This effect, known as proton relaxation enhancement (or the receptor-induced magnetization enhancement), is due to the reduced rate of rotation of CR molecule bound to a macromolecule, and in this case, the rotation rate may be reduced by two orders of magnitude. 

Receptor-induced magnetization enhancement (RIME) describes the binding of CAs to biomolecules, such as proteins or receptors. This leads to an increase in the concentration and retention time of CAs in a particular region. It also results in an increase in tr and has a tremendous effect on increasing the relaxivity [64]. 

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