Receptor chloramphenicol binding

Holtje, H.-D. and Tintelnot, M. (1984) Theoretical investigations on interactions between pharmacon molecules and receptor models. V. Construction of a model for the ribosomal binding site of chloramphenicol. Quant. Struct. -Act. Rdat., 3,6—9. 

Renoir, J. M., Mercier-Bodard, C., Hoffmann, K., Le Bihan, S., Ning, Y. M., Sanchez, E. R., Handschumacher, R. E., and Baulieu, E. E. (1995). Cyclosporin A potentiates the dexametha-sone-induced mouse mammary tumor virus-chloramphenicol acetyltransferase activity in LMCAT cells A possible role for different heat shock protein-binding immunophilins in gluco-corticosteroid receptor-mediated gene expression. Proc. Natl. Acad. Sci. USA 92,4977 981. 

Figure 51 Hypothetical receptor model for chloramphenicol (58) binding. Arginine and histidine in their postulated distances (left diagram) and the potential ribosomal protein L16 binding site (right diagram) for chloramphenicol (reproduced from Figures 4 and 5 of ref. [30] with permission from the copyright owner).

H.-D. Holtje and M. Tintelnot, Quant. Struct.-Act. Relat., 3,6 (1984). Theoretical Investigations on Interactions Between Pharmacon Molecules and Receptor Models. V. Construction of a Model for Ribosomal Binding Site of Chloramphenicol. 

COS-1, nuclear extracts containing receptor expressed in transfected COS-1 cells HL-60, cell extracts Baculovirus, recombinant receptors from the baculovirus/Sf21 expression system, wt, wild-type chimeric ER, RAR DEF or RXR D domain fused to ER DNA-binding domain CAT, chloramphenicol acetyl transferase gene LUC, luciferase gene SeAP, secreted alkaline phosphatase gene. 

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