Receiver operating characteristic curves

Fig. 2 A receiver operator characteristic curve reproduced from PubMedCentral http //www. pubmedcentral.nih.gov/articlerender.fcgi artid=1065080 and [16]...

Fig. 6 Test set receiver operator characteristic curves for M. tuberculosis Bayesian models, (a) Southern Research Institute data for >100,000 molecules (1,702 actives), (b) Novartis data for 248 molecules (34 actives), (c) FDA-approved drugs, 2,108 molecules (21 actives) (17,29)...

LLD, lower limit of detection 99th, 99th percentile reference limit ROC, receiver operator characteristic curve optimized cutoff 10% Cy lowest concentration to provide a total imprecision of 10%. 

ROC curve Receiver Operating Characteristics curve. A graphical technique of evaluating the performance of a classifier the plot of sensitivity by 1 - specificity (see sensitivity/specificity). 

Discrimination can be summarized by various single statistics, such as the area under the receiver operating characteristic curve (or the equivalent C statistic), measures, or the d statistic, although all of these measures have limitations (Royston and Sauerbrei 2004 Altman and Royston 2007 Lewis 2007). 

Wintermark M, Flanders AE, Velthuis B, Meuh R, van Leeuwen M, Goldsher D, Pineda C, Serena J, van der Schaaf I, Waaijer A, Anderson J, Nesbit G, Gabriely L Medina V, Quiles A, Pohlman S, Quist M, Schnyder P, Bogousslavsky J, Dillon WP, Pedraza S (2006) Perfusion-CT assessment of infarct core and penumbra. Receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke 37 979-985. 

FIGURE 34 (A) ROC plot on AE for lactose AUC of classifier at 0.% and (B) AE energy distributions for capped and non-cappcd tablets. Abbreviations AE. acoustic emission ROC. receiver operating characteristic curve. Source From Ref. 166. 

Figure 15-2 Receiver operating characteristic curve of prostate-specific antigen (PSA). Each point on the curves represents a different decision level.The sensitivity (true-positive rate) and I— the specificity (false-positive rate) can be read for Tests A and B. The true-positive and false-positive rates are demonstrated using 4 and IO Xg/L as decision thresholds.

Figure S-3 Receiver operating characteristic curves of prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) assays for patients with benign prostatic hyperplasia and prostatic carcinoma. Because the PSA assay curve is above the PAP assay curve at ail points, the PSA assay is the better assay for the patients tested.

Shultz EK. Multivariate receiver-operating characteristic curve analysis Prostate cancer screening as an example. Clin Chem 1995 41 1248-55. 

Although most methods very readily identify severe, uncomplicated iron deficiency, the large number of tests that have been advocated for the diagnosis of iron deficiency is a reflection of the fact that none by itself is sufficient to detect mild iron deficiency or iron deficiency in a clinically complex setting. Receiver operator characteristic curves (ROC) confirm that no one method is superior, and that different studies differ in the conclusions that they draw regarding advantages of one method over another. ... 

Figure 44-16 Receiver operating characteristic curves to establish the best discriminator limit for cardiac troponin T (cTnT) for predicting AMI.The number of true positives (/-axis) and false positives (x-axis) are reported in relation to time (h) after the onset of symptoms.The best discriminating point for cTnT is 0.20 Xg/L at 9 hours after the onset of chest pain. (Reprinted by permission of Elsevier Science from Burlina A, Zaninotto M, Seccfiiero S, Rubin D.Accorsi F. Troponin T as a morfcer of ischemic myocardial injury. Clin 6/ocbem I994 27 t 13-21. Copyright 1993 by Canadian Society of Clinical Chemists.)...

The Receiver Operator Characteristic curve (ROC curve) is a graphical plot of the sensitivity Sn versus false positive rate FPR for a binary classifier system as its discrimination threshold is varied. The ROC curve can also be represented equivalently by plotting the fraction of true positives (TP) versus the fraction of false positives (FP) (Figure C3). ROC analysis provides tools to select possibly optimal classification models. 

Receiver Operator Characteristic curve classification parameters... 

One measure of accuracy is the likelihood ratio (LR) [17]. The likelihood ratio is based on the relationship between the true positive fraction and the false positive fraction. Thus, LR = TPF/FPF. Substituting terms, the LR = sensitivity/(1-specificity). Receiver-operating characteristic curves are graphical summaries of likeli-... 

Gardner, 1. A., and M. Greiner. 2006. Receiver-operator characteristic curves and likelihood ratios Improvements over traditional methods for the evaluation and application of veterinary clinical pathology tests. Veterinary Clinical Pathology 35 8-17. 

Wintermark, M., et al., Perfusion-CT assessment of infarct core and penumbra receiver operating characteristic curve analysis in 130 patients suspected of acute hemispheric stroke. Stroke, 2006. 37(4) p. 979-85. 

Pin, J.P., and Bertrand, H.O. (2005) Virtual screening workflow development guided by the receiver operating characteristic curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4. Journal of Medicinal Chemistry, 48 (7), 2534-2547. 

Brown, C. D. Davis, H. T. (2005). Receiver operating characteristics curves and related decision measures A tutorial, Chemom. Intell. Lab. Syst. 80 24-38. 

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