Reagents functionalization required

An intramolecular reaction requires the presence of two suitably positioned functional groups, the substrate function and the reagent function, in the same molecule. The demonstration of an intramolecular process is obvious when the product is cyclic, as in this lactonization ... 

There is a cost associated with the effort needed to prepare these nanostructured materials building blocks must be found and suitably functionalized tailored linking reagents are required air sensitive handling procedures developed and byproducts carefully removed. It is therefore appropriate to ask, has the effort and expense lead to new and better catalysts ... 

Derivatization with achiral reagents is required for nonvolatile or highly polar substrates such as a-amino acids. Appropriate derivatization leads to improved resolvability by the introduction of suitable functional groups capable of hydrogen bonding or coordination. If derivatization is necessary, it has to be ensured that the chemical reaction does not lead to any racemization of the sample. 

Notes Selective oxidizing agent. Since a mechanistic requirement of this reagent functioning ability is a complexation with the substrate, it is exceedingly important that only the -OH group binds efficiently. A useful advantage of this oxidation protocol is that it takes place under essentially neutral conditions. See Dess-Martin Oxidation. 

As noted previously (Section 22.2), derivatization with a chiral derivatizing reagent (CDR) requires the presence of suitable functionality (e.g., —OH, Ar—OH,—SH,—COOH,—CO—NH2,—NRH) within the chiral analyte to serve as a reactive site. Before addressing specific issues with regard to CDR and analyte classes, it may be helpful to review general considerations for achiral derivatization in chromatographic assays. 

The data necessary to plot theoretical p-functions versus reagent volumes require the use of formation... 

Prepared in 75% yield by the bromination of caprolactam, this reagent functions as a brominating agent in the same way as N-bromosuccinimide but it does not require a peroxide catalyst or actinic light to initiate the reaction. ... 

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