Reactivity with aldehydes

The cationic polymerization of cardanol under acidic conditions has been referred to earlier [170,171], NMR studies [16] indicated a carbonium ion initiated mechanism for oligomerization. PCP was found to be highly reactive with aldehydes, amines, and isocyates. Highly insoluble and infusible thermoset products could be obtained. Hexamine-cured PCP showed much superior thermal stability (Fig. 12) at temperatures above 500°C to that of the unmodified cardanol-formaldehyde resins. However, it was definitely inferior to phenolic resins at all temperatures. The difference in thermal stability between phenolic and PCP resins could be understood from the presence of the libile hydrocarbon segment in PCP. 

Inactive A-acylhydroxylamines 135 result in free-radical scavenging of acyl radicals by nitroxides (Scheme 24, pathway a) [126, 173, 174, 191]. Alternative pathways b and c starting with NOH were proposed as well [26] and include reactivity with aldehydes or carboxylic acids formed in oxidized PO. Aldehydes generate hemiacetals 136 in the first step and are transformed into 135 after scavenging ROO. ... 

Gluten is a protein derived from wheat [14,15]. The amide groups of the peptide links in gluten proteins are capable to react with aldehydes in the same manner as other amides, e.g., urea [1]. Amine groups in lysine and arginine (aminoacids in which gluten is rich) [14] also present even more marked reactivity with aldehydes, similar to those presented by melamine [1] and phenols [1]. 

Treatment of 2,2-dimethylselenazolidines with reactive aromatic aldehydes gives exchange of carbonyl radicals (Scheme 7Ti. 

Mills and Smith (504) were the first, in 1922, to develop a systematic study of the reactivity of methyl groups fixed on nitrogen-containing heterocycles. While in alkylpyridines the 2- (or 6) and 4-positions are activated, only the 2-position in thiazole corresponds to an enhanced reactivity of the methyl groups in condensation with aldehydes 4- and 5-methylthiazoles bear inert methyl groups. Quatemization of the thiazole nitrogen enhances still further the reactivity of the methyl in the 2-position (cf. Chapter IX), but it does not increase the reactivity of a methyl group in the 4-position (504). The authors invoke the possibility for 2- (and 6) methylpyridine and 2-methylthiazole to pass, to some extent, into the reactive enamine form (245), while 4-methylthiazole could adopt such a structure only with the participation of an unusual formula such as 247 (Scheme 112). 

The primary and secondary alcohol functionahties have different reactivities, as exemplified by the slower reaction rate for secondary hydroxyls in the formation of esters from acids and alcohols (8). 1,2-Propylene glycol undergoes most of the typical alcohol reactions, such as reaction with a free acid, acyl hahde, or acid anhydride to form an ester reaction with alkaU metal hydroxide to form metal salts and reaction with aldehydes or ketones to form acetals and ketals (9,10). The most important commercial appHcation of propylene glycol is in the manufacture of polyesters by reaction with a dibasic or polybasic acid. 

In 1959 Carboni and Lindsay first reported the cycloaddition reaction between 1,2,4,5-tetrazines and alkynes or alkenes (59JA4342) and this reaction type has become a useful synthetic approach to pyridazines. In general, the reaction proceeds between 1,2,4,5-tetrazines with strongly electrophilic substituents at positions 3 and 6 (alkoxycarbonyl, carboxamido, trifluoromethyl, aryl, heteroaryl, etc.) and a variety of alkenes and alkynes, enol ethers, ketene acetals, enol esters, enamines (78HC(33)1073) or even with aldehydes and ketones (79JOC629). With alkenes 1,4-dihydropyridazines (172) are first formed, which in most cases are not isolated but are oxidized further to pyridazines (173). These are obtained directly from alkynes which are, however, less reactive in these cycloaddition reactions. In general, the overall reaction which is presented in Scheme 96 is strongly... 

Eberle has explored the synthetic possibilities of (421) with aldehydes it leads to hexa-hydropyrimido[i,2-a]indoles (73T4049). Its 5-oxo derivative (l-phenyl-5-pyrazolidinone) has a comparable reactivity (76JOC3775). 

With l,3-dimethyl-2,l-benzisoxazolium salts, however, considerable reactivity has been reported. Condensation occurs readily with aldehydes, ketones, orthoesters and diazonium salts to yield styryl, cyanine and azo compounds, respectively (78JOC1233). In the presence of triethylamine, dimerization was observed, and the reactions of the cation were considered to involve the intermediacy of the anhydro base (77JOC3929). 

Organolithium and organomagnesium reagents are highly reactive toward most carbonyl compounds. With aldehydes and ketones, the tetrahedral adduct is stable, and alcohols are isolated after protonation of the adduct, which is an alkoxide ion. 

Occasionally, a phenol may have more than one substituent on the ring before alkylation with aldehyde. If the groups are meta to one another and activating, they will enhance the electron density of the same ring positions and reinforce one another. If they are ortho or para to one another, they may increase or reduce reactivity, depending on the nature of the groups. The most common... 

Aromatic nitro compounds are often strongly colored. They frequently produce characteristic, colored, quinoid derivatives on reaction with alkali or compounds with reactive methylene groups. Reduction to primary aryl amines followed by diazotization and coupling with phenols yields azo dyestuffs. Aryl amines can also react with aldehydes with formation of Schiff s bases to yield azomethines. 

The advantages of amine-aldehyde condensates are water (or oil) soiu ble reaction products, lower operating temperatures, low eorrosivenL to, ind no reactivity with hydrocarbons... 

Equilibrium constants for reactions of various nucleophiles with a,a,a-trifluo-roacetophenone to give tetrahedral adducts were determined [5J] (equation 39). In the equilibria, all nucleophiles were found to be less reactive with trifluoro-acetophenone than with aldehydes [55] (equation 39). 

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