Range of molecular interaction

Some newer applications of FAC-MS have been described, which suggest that the technology has a strong role to play in the drug discovery process for an extremely broad range of molecular interactions. 

As we have illustrated, metal based systems have introduced a huge variety of receptors to the field of anion binding, which function through a wide range of molecular interactions. This inorganic approach to anion binding has addressed several very important goals ... 

In this equation, l is a range of molecular interaction. For low molecular weight liquid-liquid and vitreous glass systems (16, 17) y l is 5-20 A (10 A is a typical value). For polymer solutions, Debye has shown that l = R/ 6 where R is the root mean square end-to-end distance of the polymer chain. Similarly, for polymer-polymer systems, l = R yj3 on the basis of a derivation analogous to that given by DebyejFpr pplymer jolvept systems. In the latter case,... 

In contrast, Khaledi and Breyer [16] reported excellent correlations for k (instead of log k) vs. log for anionic (SDS) and cationic (tetra-decyltrimethylammonium bromide, C14TAB) surfactants on C8 and phenyl-bonded stationary phases, with compounds having various functional groups. The log k vs. log Pqw plots consistently showed a curvature. The two sets of 16 and 35 compounds used by these authors with C8 and phenyl columns, respectively, covered more than 4-orders of magnitude in hydrophobicity and represented a relatively broad range of molecular interactions, molecular shapes and sizes. In a sense, the sets consisted of several noncongeneric compounds. 

The scale of the scattered light sensitivity to structure is of the order q 1000 A of magnitude and turns to be sufficiently larger than the range of molecular interactions in liquid (far from the spinodal), and there is no -dependence in Equation 41... 

The main theoretical challenge for nonequilibrium systems is to bridge the gap in length and time scales between the molecular motion and the collective motion of the fluid, such as the translation of droplets. In top-down approaches macroscopic hydrodynamics is combined with equilibrium statistical physics. The resulting mesoscopic hydrodynamic equations partially include the effects of boundary slip, thermal fluctuations, and the long range of molecular interactions. So far, bottom-up approaches for nonequilibrium systems are only available for a small class of systems with purely diffusive dynamics. For the other liquids one has to resort to numerical simulations. 

The chaos assumption thus allows the pair correlation to be neglected outside the range of molecular interaction, thus /correlation 0 when r2 — ri > ro. 

This term is introduced when the concentration gradients are such that the average concentration varies appreciably within the range of intermolecular interactions. The greater the range of molecular interaction the larger this effect will be, so K should be related to that range. 

---