RAGE receptor

Receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin-like cell surface receptor superfamily inter-acting with several SI00 proteins. 

Hofmann MA, Drury S, Fu C et al (1999) RAGE mediates a novel proinflammatory axis a central cell surface receptor for SlOO/calgranulin polypeptides. Cell 97 889-901... 

Over 100 years ago, a debate was raging between the two most famous neuroscientists in the world concerning the nature of the nervous system. Golgi believed that all neurons were connected in a nerve net or syncytium whereas Ramon y Cajal believed that neurons were separated from each other by tiny spaces called synapses. Cajal proved to be correct, and it was later learned that neurons communicate across the synapse by releasing chemical substances known as neurotransmitters or by releasing electrical charges. Because chemical neurotransmission is much more common than electrical transmission, especially in the brain, and it is chemical neurotransmission that is modulated by psychiatric medicines, our discussion will focus on the chemotransmitter process. In simplest terms, the process of chemical neurotransmission occurs in three steps neurotransmitter production, neurotransmitter release, and neurotransmitter action on specific receptors. 

Schmidt, A.M. and Stern, D.M. (2001) Receptor for AGE (RAGE) is a gene within the major histocompatibility class III region implications for host response mechanisms in homeostasis and chronic disease. Front. Biosci. 6, D1151-D1160. 

Receptor for advanced RAGE Glycosylated proteins RMT Blood to brain [40,41]... 

S100A8/S100A9 seem to bind and activate various surface receptors such as heparin sulfate proteoglycans (Srikrishna et al., 2001), CD36 (Kerkhoff et al., 2001), and RAGE (Hermani et al., 2006). 

Arumugam T, Simeone DM, Schmidt AM, Logsdon CD. 2004. SI OOP stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE). J Biol Chem 279(7) 5059-5065. 

Bucciarelli LG, Wendt T, Rong L, Lalla E, Hofmann MA, Goova MT, Taguchi A, Yan SF, Yan SD, Stern DM, Schmidt AM. 2002. RAGE is a multiligand receptor of the immunoglobulin superfamily implications for homeostasis and chronic disease. Cell Mol Life Sci 59(7) 111 7—1128. 

Chavakis T, Bierhaus A, Al-Fakhri N, Schneider D, Witte S, Linn T, Nagashima M, Morser J, Arnold B, Preissner KT, Nawroth PP. 2003. The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins a novel pathway for inflammatory cell recruitment. J Exp Med 198(10) 1507-1515. 

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