Radiotherapy concepts

Steel GG, Peckham MJ. Exploitable mechanisms in combined radiotherapy-chemotherapy the concept of additivity. Int JRadiat Oncol Biol Phys 1979 Jan 5(1) 85—91. 

There is a long-standing interest in the question of charge and excitation transfer through DNA. This largely resulted from an attempt to protect or to sensitize DNA against the effects of ionizing radiation in radiotherapy. The concept of... 

In 1968 the IAEA with the participation of WHO conveyed a panel of experts to discuss the dosimetric requirements of radiotherapy centres. The panel recommended the setting up of dosimeter calibration centres (later called Secondary Standard Dosimetry Laboratories—SSDLs) in developing countries. In 1974 experts, mainly from the large national standard laboratories, discussed the concept of SSDLs and their role in metrology. An SSDL was defined as a laboratory designated by the competent national authority to undertake dosimetry calibrations. For the proper function of the SSDLs, the need for dose intercomparison and for coordination of the work of individual laboratories was recognised. This ultimately led to the establishment of the international lAEAAVHO Network of SSDLs. 

Leopold WR, Sebolt-Leopold JS. Chemical approaches to improved radiotherapy. In Valeriote FA. Corbett TH, Baker LH, eds. Cytotoxic Anticancer Drugs Models and Concepts for Drug Discovery and Development. Boston Kluwer, 1990 179-196. 

Radiotherapy for Non-Malignant Disorders Contemporary Concepts and Clinical Results... 

Steel GG, Peckham MJ (1979) Exploitable mechanisms in combined radiotherapy-chemotherapy the concept of additivity. Int J Radiat Oncol Biol Phys 5 85-91 Stewart DJ, Chiritescu G, Dahrouge S, et al. (2007) Chemotherapy dose-response relationships in non-small cell lung cancer and implied resistance mechanisms. Cancer Treat Rev 33 101-137... 

This concept has been applied for most cytoreductive therapy such as chemotherapy or radiotherapy. 

The progress in experimental studies Is complemented by the development of biophysical models to describe radiation effects. Modeling plays an Important role for the mechanistic understanding of radiation action as well as for practical applications in radiation protection and radiotherapy. This section will thus give a brief overview over some basic concepts developed In particular to describe the biological action of heavy charged particle beams. 

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