Chemotherapy dose-response relationship

Steel GG, Peckham MJ (1979) Exploitable mechanisms in combined radiotherapy-chemotherapy the concept of additivity. Int J Radiat Oncol Biol Phys 5 85-91 Stewart DJ, Chiritescu G, Dahrouge S, et al. (2007) Chemotherapy dose-response relationships in non-small cell lung cancer and implied resistance mechanisms. Cancer Treat Rev 33 101-137... 

Focan C, Andrien JM, Closon MT, Dicato M, Driesschaert P, Focan-Henrard D, Lemaire M, Lobelle JP, Longree L, Ries F. Dose-response relationship of epirubicin-based first-line chemotherapy for advanced breast cancer a prospective randomized trial. J CUn Oncol 1993 ll(7) 1253-63. 

Thirty randomized, controlled trials from 1975 to 1996 were analyzed to quantify the antiemetic efficacy and adverse effects of cannabis when given to 1366 patients receiving chemotherapy. Oral nabUone, oral dronabinol, and intramuscular levonantradol were compared with conventional antiemetics (prochlorperazine, metoclopramide, chlor-promazine, thiethylperazine, haloperidol, domperidone, and aliza-pride) or placebo. Across all trials, cannabinoids were slightly more effective than active comparators and placebo when the chemotherapy regimen was of moderate emetogenic potential, and patients preferred them. No dose-response relationships were evident to the authors. The cannabinoids were also more toxic side effects included euphoria, drowsiness, sedation, somnolence, dysphoria, depression, hallucinations, and paranoia. The efficacy of cannabinoids as compared to SSRls has not been studied. Use of these agents should be considered when other regimens do not provide desired efficacy. 

Recombinant erythropoietin therapy, in conjunction with adequate iron intake, can be highly effective in a number of anemias, especially those associated with a poor erythropoietic response. There is a clear dose-response relationship between the epoetin alfa dose and the rise in hematocrit in anephric patients, with eradication of their anemia at higher doses. Epoetin alfa is also effective in the treatment of anemias associated with surgery, acquired immunodeficiency syndrome (AIDS), cancer chemotherapy,... 

Based on this dose-response relationship for cytotoxic drugs the aim of regional chemotherapy will be ... 

Reliable prediction of therapy response for different tumor entities depends upon knowledge of typically observed T/N ratios. A relation between T/N ratios and therapy success has already been described for hepatic artery chemotherapy [15, 36]. Higher doses and higher T/N ratios have also been shown to be associated with improved survival after SIRT [16], which is in line with observations made by other authors [33, 39, 56]. However, in a recent study, no relationship between the pattern of MAA uptake by metastatic colorectal liver tumors and response to microsphere treatment... 

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