Radioembolization results

Andrews JC, Walker SC, Ackermann RJ et al (1994) Hepatic radioembolization with yttrium-90 containing glass microspheres preliminary results and clinical follow-up. J Nucl Med 35 1637-1644... 

Radioembolization represents an effective tool for the treatment of primary and secondaryliver tumors. Adequate use of this therapy requires knowledge and a multidisciplinary effort in order to obtain optimal results and avoid therapy-specific complications. A great deal of research has been undertaken in order to understand the angiographic, technical... 

In contrast to external beam radiation microspheres represent point sources of radiation with a very limited radiation range of a few millimeters. Moreover, radioembolization in terms of SIRT combines two different therapeutic principles (1) embolization by microparticles acting as the carrier of the radiation, resulting in microvascular occlusion, with (2) simultaneous brachytherapy by implantation of radioactive microparticles. Assuming an increased peri- and intratumoral (neo-)vasculariza-tion the microparticles will deliver a very high dose of radiation rather selectively to the tumor tissue,... 

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