Radiation-induced normal tissue injury

Improved understanding of the molecular mechanisms underlying radiation-induced normal tissue injury has identified a number of molecular pathways, pro-fibrogenic growth factors, inflammatory cytokines, and chronic oxidative stress that can be tcffgeted to cunelio-rate normal tissue injury. 

Approaches to prevent, mitigate, and/or treat radiation-induced normal tissue injury have been investigated in pre-clinical and clinical studies with varying degrees of success. 

A number of cytokines, growth factors, and oxidant-generating enzymes have been implicated in the aforementioned processes and have been used as potential targets in an attempt to ameliorate and/or treat radiation-induced normal tissue injury. A growing body of evidence points toward a complex web of... 

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