Rab geranylgeranyl transferase RabGGTase

Prenylated small GTPases represent major hubs in most membrane-connected signaling networks. Rab prenylation is mediated by Rab geranylgeranyl transferase (RabGGTase), which works together with an adaptor protein, Rab escort protein (REP). Rab cycling between membranes and the cytosol is made possible by interaction with the GDP dissociation inhibitor (GDI). Both GDI and REP function as molecular chaperones, which can solubilize the prenylated Rab proteins in the cytosol. 

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