QVAR

Beconase AQ, QVAR, Vanceril, Vanceril Double Strength... 

Qvar 84 mcg/puff, 1 puff 4 times a day Proventil HFA2 puffs PRN for symptoms Flonase 1 puff in each nostril daily... 

Mucomyst) Beclomethasone, nasal (Beconase AQ) Beclomethasone, inhaler (QVAR)... 

Davies R, Leach C, Lipworth B, Shaw R. Asthma management with HFA-BDP (Qvar). Hosp Med 1999 60(4) 263-70. 

Brand Name(s) Beclovent, Beconase, Beconase AQ, Qvar, Vancenase, Vancenase AQ, Vancenase AQ DS, Vanceril, Vanceril DS Cfiemical Class Glucocorticoid, synthetic... 

QVAR autohaler Beclomethasone HFA 134a, ethanol Solution 1.0 17... 

He is started on salbutamol metered dose inhaler (MDI) two puffs when required and beclometasone (Qvar) 50 micrograms twice daily. 

Beclometasone Aldecin , Becloforte , Becodisks , Beconase , Becotide , Propaderm , Qvar ... 

QVAR (3M) Beclomethasone dipropionate September 2000 HFA 134a, ethanol, oleic acid Solution... 

Rahmatalla, M. F., Zuberbuhler, P. C., Lange, C. F., and Finlay, W. H. (2002), In vitro effect of a holding chamber on the mouth-throat deposition of QVAR (hydrofluoroalkane-beclomethasone dipropionate), J. Aerosol Med., 15,379-385. 

Trade names Beconase AQ (GSK) Qvar (3M) Vanceril (Schering)... 

Azutranquil oxazepam beclomethasone Beconase AQ, Qvar, Vanceril... 

The main formulation challenge with HFA pMDI has been the poor solubility of the surfactants that were used in CFC products. Most pMDI formulations are suspensions of fine powder in propellant, and in order to obtain acceptable dose uniformity these suspensions usually require surfactants to stabilize them. The inability to use conventional surfactants has therefore led to a range of diverse formulation approaches. These encompass drug solubilization using cosolvents (Qvar is an example), new surfactants, coating particles with surfactant, and particle engineering (Fig. 3). However, as is the case with most... 

Ethanol/ Dehydrated Alcohol/ Alcohol Azmacort, Isuprel, Primatene Mist, Tornalate, Qvar, Atrovent HFA, Proventil HFA, Xopenex HFA, Aerospan HFA, Alvesco Co-solvent 34.5%... 

Figure 10.10 Auxiliary devices (from left to right) rear Nebuchamber (AstraZeneca), Volumatic (Allen Hanburys) spacers, front Flutide MDI (GlaxoWellcome), Qvar MDI (3M Health Care), Easi-breathe BAI (Baker Norton).

CB s asthma is currently being treated with a low-dose of the inhaled corticosteroid beclomethasone dipropionate (QVAR, 40 pg b.i.d.). She is in your pharmacy now with prescriptions for both chronic medications written by her new provider. After taking her medical history and reviewing her psychosocial situation, you recognize that she has many risk factors for near-fatal asthma" and believe she should have ready access to rescue therapy in case she experiences an acute episode of severe bronchoconstriction. Consider the structures of the adrenergic agents drawn below, and prepare to make a therapeutic recommendation to CB s new physician. 

Differences in the formulation for HFC MDIs can lead to differences in the amount of drug deposited in the lung and also where it is deposited. Pharmaceutical data may not predict with precision the relative potency or the therapeutic ratio in patients. For example, Qvar (3M), the only formulated HFC beclomethasone with published information, has a smaller particle size, and radiolabeling data show that up to eight times the dose is delivered to the lungs, while three times less is delivered to the oropharynx (9). Clinical studies have shown that Qvar is equivalent to twice the dose of CFC beclomethasone (10,11)— i.e., the dose will need to be halved when transition occurs. In contrast, HFC fluticasone (Glaxo Wellcome) more closely resembles the CFC version, and studies have shown clinical equivalence at the same dose (12,13). 

Cohen RM. Assessment of switching patients taking CFC-BDP to Qvar at approximately half the dose. Am J Respir Ciit Care Med 1998 157 A405. 

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