Quinuclidine complex with

The long known132 electron donor-acceptor complexes between tertiary amines and carbon tetrahahdes are simple systems. Thus, l,4-diaza[2,2,2]bicyclooctane (DABCO) or quinuclidine afford solid complexes with carbon tetrabromide142. 

As seen in Figure 10a, the C CP/MAS NMR spectrum of the quinuclidine complex shows the expected asymmetry (for instance, different signals for C-8a and C-9a) due to the asymmetric position of the lithium cation relative to the carbon framework in accordance with the X-ray investigation . The observed linewidths are not exceptionally large, and only small effects on the linewidths were observed when Li was substituted by Li, as shown in Figure 10b. 

FIGURE 11. CP/MAS NMR spectra of fluorenyUithium complexes (a) Quinuclidine complex, (b) DEE complex, (c) TMEDA complex and (d) TFIF complex. Reprinted with permission from Reference 128. Copyright 1990 American Chemical Society... 

Some bridgehead amines [l,4-diazabicyclo-[2,2,2]octane (102), quinuclidine (103) and quinuclidine-3-ol] form 1 1 molecular complexes with quinones 104. Formation of 2 1 (amine/quinone) complexes was observed in solutions of DABCO (102) and chloranil (104, R = Cl). These tertiary amines are able to form complexes, while non-bridgehead amines (triethylamine, piperidine) cannot because of steric hindrance or nitrogen inversion183. Stable complexes may be predicted (by CNDO/2 calculations) for... 

The quinuclidine complex of Eu(DPM)3 gives rise to a polyhedron consisting of a distorted octahedron formed by six oxygen atoms with quinuclidine nitrogen located above the center of one of the faces, resulting in overall threefold symmetry. The molecular structure [71] of [Eu(DPM)3 quinuclidine] is shown in Fig. 5.10. 

The oxide gives very stable tbp adducts with a variety of amines like pyridine or quinuclidine. It also forms highly colored but weak complexes with arenes.101 This has been exploited102 to convert benzene to polycyclohexane derivatives. 

The (ester) hydrolysis of BZ over a range of conditions of pH and temperature has been investigated (Hull et ak, 1979). Bromocresol Green forms a colored complex with 3-quinuclidmyl esters of hydroxyacetic acids, which has been used in the spectrophotometric analysis of mixtures containing these esters and 3-quinucfidinol (Stan kopv et ak, 1997). Analysis of the mass spectra of a number of quinuclidine derivatives is available (Vincze et ak, 1980). BZ has been safely destroyed pyrolytically (Jensen, 1991). 

Complexes with this formulation satisfy the generally accepted criteria for structural features required in an antitumor-active platinum complex, but are expected to possess kinetic advantages when compared to the prototype antitumor platinum complex, cis-dichloro-diamineplatinum (II). Complexes have been prepared where L is a monoprotonated diamine and also where L is a protonated amino-olefin. All complexes have been examined for cytotoxicity against L1210 leukemia in cell culture, and selected compounds have been tested for antitumor activity vivo (LI210 leukemia in BDF mice). One compound, where L is protonated 3-amino-quinuclidine, has significant vivo activity, with T/C approaching 150%. 

Figure 1. Br0nsted-type plots for the reactions of substituted quinuclidines with the dianions of 2,4-dinitrophenyl phosphate complexed with calcium (upper line), 2,4-dinitrophenyl phosphate (middle line), and p-nitrophenyl phosphate (lower line) at 39 °C, ionic strength 1.0 (KCl) ( ) and ionic strength 1.5 (KCl) (o) (Reproduced from reference 12. Copyright 1986 American Chemical Society.)...

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