Quinolines synthesis using transition metal

The other direction concerns the use of immobilized transition metal catalysts in the synthesis of libraries of organic compounds of interest in therapeutic drug discovery. One such strategy uses immobilized catalysts (e.g., scandium complexes), leading to efficient library syntheses of quinolines, amino ketones, and amino acid esters.72,73... 

Interest in new compositions and new synthetic routes in the context of catalysis is growing, and recent examples of the synthesis and use of non-oxidic, ceramic compositions in catalysis include SiC as a support for Ni or Pt in CO hydrogenation (2), SiC as a support for Co and Mo for thiophene hydrodesulphurisation (3), transition metal (Ti, Ta, Mo or W) carbides for methanol decomposition (4), early transition metal carbides, nitrides or borides for hydrodenitrogenation of quinoline (5), and the synthesis of high surface area molybdenum carbide (6). 

Contrary to majority of modern methods of synthesis of indoles, these reactions do not need transition metal catalysis, so the produced indoles can by directly used in pharmaceutical and other industries. A plethora of other heterocyclic systems such as quinolines [28], benzisoxazoles [26, 27], acridines [27], phenazines, [85] etc. can be similarly constructed via S ArH reactions. 

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