Quinine ventricular arrhythmias caused

VENLAFAXINE 1. ANTIARRHYTHMICS - amiodarone, disopyramide, procainamide, propafenone 2. ANTIBIOTICS — macrolides (especially azithromycin, clarithromycin, parenteral erythromycin, telithromycin), quinolones (especially moxifloxacin), quinupristin/ dalfopristin 3. ANTICANCER AND IMMUNOMODULATING DRUGS -arsenic trioxide 4. ANTIDEPRESSANTS-TCAs 5. ANTIEMETICS-dolasetron 6. ANTIFUNGALS-fluconazole, posaconazole, voriconazole 7. ANTIHISTAMINES-terfenadine, hydroxyzine, mizolastine 8. ANTIMALARIALS -artemetherwith lumefantrine, chloro-quine, hydroxychloroquine, mefloquine, quinine 9. ANTIPROTOZOALS -pentamidine isetionate 10. ANTIPSY-CHOTICS - atypicals, phenothiazines, pimozide 11. BETA-BLOCKERS -sotalol 12. BRONCHODILATORS-parenteral bronchodilators 13. CNS STIMULANTS - atomoxetine Risk of ventricular arrhythmias, particularly torsades de pointes Additive effect these drugs cause prolongation of the Q-T interval Avoid co-administration... 

Grant and Iliescu (23) preferred to evaluate quinine potency by an indirect method. They administered quinine in 0.6-g. doses to patients with auricular fibrillation. These subeffective but safer doses do not eliminate the arrhythmia but do cause a decrease in the auricular rate and an increase in ventricular rate. Again quinine proved to be inferior to quinidine quinine decreased the average auricular rate 86 beats/min. and increased the ventricular rate 15 comparable figures for quinidine are 161 and 45. Gold (2) reports that the maximum limit of reduction of auricular rate is twice as high for quinidine as for quinine quinine, even at 2.0-g. doses, produced only the slowing that quinidine effected at a 0.3-g. dose. 

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