Sparfloxacin Quinidine

If patient Is taking agents capable of significantly prolonging QTc Interval (e.g., pimozide thioridazine selected antlarrhythmics such as quinidine, disopyramide, amlodarone, and sotalol selected antibiotics such as moxifloxacin and sparfloxacin)... 

Clinically important, potentially hazardous interactions with abarelix, acenocoumarol, amisulpride, amprenavir, anisindione, anticoagulants, arsenic, astemizole, carbimazole, celiprolol, ciprofloxacin, dabigatran, degarelix, dicumarol, digoxin, diltiazem, enoxacin, fentanyl, fosamprenavir, gatifloxacin, grapefruit juice, lomefloxacin, methotrexate, moxifloxacin, nilotinib, norfloxacin, ofloxacin, oxprenolol, quinidine, quinolones, rifabutin, rifampin, rifapentine, ritonavir, simvastatin, sparfloxacin, sulpiride, tacrolimus, tipranavir, verapamil, warfarin, zuclopenthixol... 

Clinically important, potentially hazardous interactions with amiodarone, bepridil, cisapride, disopyramide, droperidol, erythromycin, flecainide, levodopa, pentamidine, procainamide, quinidine, sotalol, sparfloxacin, terfenadine, thioridazine... 

Clinically important, potentially hazardous interactions with abacavir, amiodarone, bretylium, chlorpromazine, ciprofloxacin, disopyramide, enoxacin, fluphenazine, gatifloxacin, lomefloxacin, mesoridazine, moxifloxacin, norfloxacin, ofloxacin, phenothiazines, procainamide, prochlorperazine, promethazine, quinidine, quinolones, sotalol, sparfloxacin, thioridazine, trifluoperazine... 

Clinically important, potentially hazardous interactions with amphetamines, aprepitant, astemizole, atazanavir, azithromycin, azole antifungals, clarithromycin, darunavir, dirithromycin, erythromycin, fluoxetine, fosamprenavir, grapefruit juice, imatinib, indinavir, itraconazole, ketoconazole, methylphenidate, nefazodone, nelfinavir, nilotinib, pemoline, phenothiazines, protease inhibitors, quinidine, ritonavir, saquinavir, sertraline, sparfloxacin, sulpiride, telithromycin, thioridazine, tipranavir, tricyclic antidepressants, troleandomycin, voriconazole, zileuton, ziprasidone... 

Leukopenia, eosinophilia, and mild elevations in serum transaminases occur rarely. Prolongation of the QT interval has been observed with sparfloxacin and to a lesser extent with gati-floxacin and moxifloxacin. Quinolones probably should be used only with caution in patients who are taking certain antiarrhythmics, including amiodarone, quinidine, and procainamide (see Chapter 34). 

Ciprofloxacin normally appears not to interact with quinidine to a clinically relevant extent An increased risk of torsade de pointes might be expected if quinidine is used with gatifloxacin, moxifloxacin, or sparfloxacin, and possibly levofloxacin. 

Some quinolones can prolong the QT interval, and would be expected to increase the risk of torsade de pointes arrhythmias when used with quinidine. Of the quinolones used clinically, gatifloxacin, moxifloxacin, and sparfloxacin are known to prolong the QT interval (see Table 9.2 , (p.257)). There is also evidence that levofloxacin may prolong the QT interval (see Amiodarone + Quinolones , p.249). These quinolones should... 

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