Quinidine soluble salt

Lipophilic prodrugs. These include slightly soluble salts (e.g., quinidine polygalacturonate, Cardioquin ), esters (e.g., enalapril, Vasotec ... 

C20H24N2O2, Mr 324.42 cryst. bitter substance, mp. 177 °C (as trihydrate mp. 57 °C), [a]o - 117° (CHCI,), Q. is a quinoline alkaloid, poorly soluble in water, readily soluble in organic solvents (alcohol, chloroform). It dissolves in oxygen-containing acids with a blue fluorescence like quinidine. Like other Cinchona alkaloids Q. forms soluble salts in plants, especially with quinic acid and tannins, e.g., as quinine citrate. The sulfate and hydrochloride of Q. are used in therapy. Q. is also used in racemate separations. "Quini-... 

Quinidine is alkaline in solution and behaves as a diacidic base forming two series of salts. The neutral sulphate, Bj. H2SO4.2HjO, crystallises from hot water in colourless prisms, soluble in water (1 in 98 to 100 at 15°, or 1 in 7 at 100°), more so in alcohol or chloroform, and scarcely in ether. It is dextrorotatory, [a]D +184-17° (CHCI3). The acid sulphate, B. H2SO4.4H2O, forms hair-like, colourless needles, soluble in 8-7 parts of water at 10° + 247-8° (c = M/10, HjO) or + 256-4° (c = M/40,... 

Quinidine. Formula see quinine. C20H24N2O2, Mr 324.42, [a]o +230° (CHCI3) a typical Cinchona alkaloid, the dextrorotatory diastereomer of quinine from cinchona bark. Crystal plates, poorly soluble in water, better soluble in alcohol, ether, chloroform, mp. 175 °C, obtained from the mother liquor from the isolation of quinine and purified by formation of salts and precipitation. It is also obtained in yields of over 40% semisynthetically from quinine. 

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