Quinidine Polygalacturonate

Ercoli, A. and Gardi, R. U.S. Patent 3,159,620 December 1,1964 assigned to Francesco Vismara S.p.A. (Italy) 

Therapeutic Function Antiarrhythmic Chemical Name See structural formula Common Name — 

100 grams of polygalacturonic acid are dissolved in 1 liter of a 60% (v/v) mixture of meth- 

The pH of the reaction mixture is taken both before and after the addition of the iast portion of the quinidine-methanol solution. The mixture is gently warmed (30° to 50°C), and the pH determined at 20 minute intervals. At the end of 4 hours, or when the reaction has gpne to completion as evidenced by the pH of the mixture (between pH 6.5 and 7.5), the stirring is then stopped and the mixture cooled to 0°C and filtered. The solvent is evaporated to dryness under reduced pressure, utilizing as little heat as is feasible. The dried residue is powdered and suspended in 10 volumes of methanol and filtered. The insoluble powder is dried, and is quinidine polygalacturonate, melting at 180°C with decomposition. 

Cardioquin Cardioquin Cardloquine Galactoquln Galatturil-Chinidina Naticardina Neochlnidin Ritmocor 

Chemical Abstracts Registry No. 654S4.56-2 Trade Name Manufacturer 

Cardioquin Cardioquin Cardioquine Galactoquin Galattu ri. Chinidina Naticardina Neochinidin Ritmocor 

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Oral sustained-release 324 mg tablets Parenteral 80 mg/mL for injection Quinidine polygalacturonate [60% quinidine base] (Cardioquin)... 

Lipophilic prodrugs. These include slightly soluble salts (e.g., quinidine polygalacturonate, Cardioquin ), esters (e.g., enalapril, Vasotec ... 

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