Quinacetophenone

Methoxyphenylurea, 31,10,13 Methyl -acetylbenzoate, 32, 81 Methyl acrylate, 30, 65 32, 86 y-Methylallophanate, 32, 62 Methylamine, 30, 60 4 -Methyl-2-aminobenzophenone, 32,12 N-Methylaniline, 30, 62 31,110 N-Methylarylamines, preparation by reductive alkylation, 30, 59, 60 Methylation, of e-caprolactam, 31, 72 of quinacetophenone, with dimethyl sulfate, 31, 91 with methyl iodide, 31, 90 2-Methyl-3,l,4-benzoxaz-4-one, 32, 12 N-Methyl-a-bromo-n-butyranilide, 30, 63... 

Quaternary ammonium salt, benzoyl-choline chloride and iodide, 30, 10 Quinacetophenone, 31, 90 Quinacetophenone dimethyl ether, 31, 91... 

QUINACETOPHENONE MONOMETHYL ETHER (Acetophenone, 2-hydroxy-5-methoxy-)... 

In a 1-1. round-bottomed flask fitted with a reflux condenser and a calcium chloride guard tube are placed 30.0 g. (0.197 mole) of quinacetophenone2 (Note 1) and 300 ml. of acetone (Note 2). The mixture is warmed on a steam bath to dissolve the quinacetophenone. The resulting greenish solution is cooled to room temperature under tap water, and 28 g. (0.20 mole) of anhydrous potassium carbonate is added followed by 42 g. (0.295 mole) of methyl iodide. The mixture is allowed to reflux on a water bath at 60-70° for about 6 hours (Note 3). 

The brown solution remaining in the distilling flask is filtered while hot on being cooled it gives 6-7 g. of brownish needles of crude quinacetophenone. 

Quinacetophenone monomethyl ether has been prepared by the methylation of quinacetophenone with dimethyl sulfate and alkali,3 and by the partial demethylation of quinacetophenone dimethyl ether.4 It has also been obtained as a by-product in the preparation of quinacetophenone dimethyl ether.6... 

Methylation. For esterification of a carboxylic acid dissolve 0.1 mole of acid in methanol, add 15.5 g. of methyl iodide and 14 g. of potassium carbonate, and stir overnight. Quinacetophenone is converted into a monomethyl ether by cooling a solution in acetone to room temperature, adding potassium carbonate and methyl... 

O-MethykUioH. Quinacetophenone is converted into the dimethyl ether by alternate addition of dimethyl sulfate and aqueous sodium hydroxide to a solution of the substance In 95% ethanol. Anhydrous D-glucose on reaction in aqueous... 

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