Quinacetophenone monomethyl

QUINACETOPHENONE MONOMETHYL ETHER (Acetophenone, 2-hydroxy-5-methoxy-)... 

Quinacetophenone monomethyl ether has been prepared by the methylation of quinacetophenone with dimethyl sulfate and alkali,3 and by the partial demethylation of quinacetophenone dimethyl ether.4 It has also been obtained as a by-product in the preparation of quinacetophenone dimethyl ether.6... 

Methylation. For esterification of a carboxylic acid dissolve 0.1 mole of acid in methanol, add 15.5 g. of methyl iodide and 14 g. of potassium carbonate, and stir overnight. Quinacetophenone is converted into a monomethyl ether by cooling a solution in acetone to room temperature, adding potassium carbonate and methyl... 

Quinacetophenone is similarly monomethylated with methyl iodide-potassium carbonate, but the dimethyl ether is formed with excess dimethyl sulphate and caustic soda [8]. Methyl-ation of catechol groups can be prevented by carrying out the reaction in the presence of a borate salt. A useful preparation of 3-0-methylgallic acid (17) is based on this principle [33]. 

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