Quest synthesis technology

Quest Synthesis Technology. Quest 210 is designed for up to 20 reactions in 5-or 10-mL reaction vessels. Each of the 20 vessels can be efficiently stirred, heated, or cooled, and maintained under an inert atmosphere. Quest 205 is designed for synthesis on a large scale, with two banks of five 100-mL reaetion vessels. 

Work in our laboratories has demonstrated that free-radicals can be harnessed to provide beneficial products and chemical technologies. This paper highlights some of our recent quests for the Holy Grail of free-radical chemistry and includes the preparation of selenium-containing antibiotics, carbohydrates, antioxidants and anti-inflammatory agents and the development of reagents for use in enantioselective synthesis. 

This was achieved using die Quest 205 apparatus from Argonaut Technologies (Basel, Switzerland). Combination of parallel syndiesis with online work-up and sample collection allows synthesis procedures using one single instrument. Each reaction vessel has a port at the top, a drain valve at the bottom and inert gas to control draining time. This gives a number of options for on-line work-up such as liquid-liquid exfraction or solvent evaporation. 

Dr. Mukund Chorghade then introduces readers to the field of process chemistry the quest for the elucidation of novel, cost-effective, and scalable routes for production of active pharmaceutical ingredients. The medicinal chemistry routes used in the past have often involved the use of cryogenic reactions, unstable intermediates, and hazardous or expensive reagents. A case smdy of the development of a process for an antiepileptic drug is presented readers will also see how problems in the isolation, structure elucidation, and synthesis of metabolites were circumvented. Described is an interesting application of the technology of metalloporphyrins assisted metabolite prediction, estimation, quantitation and synthesis. 

Machine-assisted synthesis Quest 210 Parallel Synthesizer with Auto-Solvent Wash (ASW) from Argonaut Technologies (San Carlos, C A). However, any peptide synthesizer that is TFA compatible can be used. 

---