Quaternary ammonium compounds analysis

Reverse phase -for quaternary ammonium compound analysis [QUATERNARY AMMONIUM COMPOUNDS] (Vol 20)... 

GiovanneUi, D. and Abballe, F. Aliphatic long chain quaternary ammonium compound analysis by ion-pair chromatography coupled with suppressed conductivity and UV detection in lysing reagents for blood cell analysers. J. Chromatogr. A. 2005, 1085,... 

Berberine Phenyl ethyl ami nes,neuroleptic amines,quaternary ammonium compounds Analysis in coptis species Separation by reversed-phase ion-pair HPLC... 

Mass spectral analysis of quaternary ammonium compounds can be achieved by fast-atom bombardment (fab) ms (189,190). This technique rehes on bombarding a solution of the molecule, usually in glycerol [56-81-5] or y -nitroben2yl alcohol [619-25-0], with argon and detecting the parent cation plus a proton (MH ). A more recent technique has been reported (191), in which information on the stmcture of the quaternary compounds is obtained indirectly through cluster-ion formation detected via Hquid secondary ion mass spectrometry (Isims) experiments. 

The use of ion pairing agents, such as sodium benzenesulfonate, may be helpful in the analysis of complex mixtures of quaternary ammonium compounds, as they modify their retention times418. 

Martin H) has written a perceptive analysis of the possible ways in which an ionized species may behave in various models and contribute to or be responsible for a given activity. QSAR studies that have dealt with ion-pair partitioning include a study of fibrinolytics ( ) and the effect of benzoic acids on the K ion flux in mollusk neurons ( ). Schaper (10) recently reanalyzed a large number of absorption studies to include terms for the absorption of ionized species. Because specific values were not available for log Pj, he let the relation between log Pi and log P be a parameter in a nonlinear regression analysis. In most cases he used the approximation that the difference between the two values is a constant in a given series. This same assumption was made in the earlier studies (, ) Our work suggests that the pKa of an acid can influence this differential (see below). The influence of structure on the log P of protonated bases or quaternary ammonium compounds is much more complex (11,12) and points out the desirability of being able to easily measure these values. 

Mass spectral analysis of quaternary ammonium compounds can be achieved by last-atom bombardment (lab) ms. 

As an example of the type of studies performed in environmental target compound analysis, the optimization and method development for the quantitative LC-MS analysis of quaternary ammonium compounds, especially paraquat and diquat, is briefly reviewed. The type of ions observed for paraquat and diquat strongly depends on the experimental conditions (Ch. 7.2.7). 

Blowing agents include azodicarbonamide, azodiisobutyronitrile, etc. Antistatic agents include quaternary ammonium compounds, etc. With the added complexity due to the presence of these compounds, the analysis of polymeric blends and of practical objects made from polymers containing additives is not always simple. 

In the field of cation analysis, ion-pair chromatography is the preferred method for the separation of amines of all types. While short-chain aliphatic amines (C3 to C3) and some smaller aromatic amines [39] can also be separated on surface-sulfonated cation exchangers, ion-pair chromatographic applications have been developed for the separation of structurally isomeric amines, alkanolamines, quaternary ammonium compounds, arylalkylamines, barbiturates, and alkaloids. 

In the field of surface-active cations, ion-pair chromatography is predominantly applied to the analysis of quaternary ammonium compounds, pyridine, pyrrolidine, and piperidine quatemisates, and for sulfonium, phosphonium, ammonium, and hydrazin-ium salts. 

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