Quantitative structure-retention reversed-phase liquid

Kaliszan, R. Quantitative-structure-retention relationships applied to reversed-phase high-performance liquid chromatography. J. Chromatogr. 1993,... [Pg.351]

Quantitative Structure-Retention Relationships in Reversed-phase Liquid Chromatography... [Pg.109]

A quantitative analysis of the structure-retention relationship can be derived by using the relative solubility of solutes in water. One parameter is the partition coefficient, log P, of the analyte measured as the octanol-water partition distribution. In early work, reversed-phase liquid chromatography was used to measure log P values for drug design. Log P values were later used to predict the retention times in reversed-phase liquid chromatography.The calculation of the molecular properties can be performed with the aid of computational chemical calculations. In this chapter, examples of these quantitative structure-retention relationships are described. [Pg.109]

Braumann, T., Weber, G., Grimme, H. (1983) Quantitative structure-activity relationship for herbicides. Reversed-phase liquid chromatographic retention parameter log kw versus liquid-liquid partition coefficient as a model of the hydrophobicity of phenylureas s-tria/ines and phenoxycarbonic acid derivatives. J. Chromatogr. 261, 329-343. [Pg.504]

R. Kaliszan,M. A. van Straten,M. Markuszewski, C. A. Cramers and H. A. Claessens, Molecular mechanism of retention in reversed-phase high-performance liquid chromatography and classification of modern stationary phases by using quantitative structure-retention relationships,/. Chromatogr. A 855 (1999),455-486. [Pg.73]

Kaliszan, R., Kaliszan, A., Noctor, T.A., Purcell, W.P. and Wainer, I.W. (1992a). Mechanism of Retention of Benzodiazepines in Affinity, Reversed Phase and Adsorption High Performance Liquid Chromatography in View of Quantitative Structure-Retention Relationships. J.Chro-mat., 609,69-81. [Pg.593]

Kaliszan, R. (1993). Quantitative Structure Retention Relationships Applied to Reversed Phase High Performance Liquid Chromatography. J.Chromat., 656A, 417-435. [Pg.593]

Aschi, M., D Archivio, A.A., Maggi, M.A., Mazzeo, P. and Ruggieri, F. (2007) Quantitative structure-retention relationships of pesticides in reversed-phase high-performance liquid chromatography. Anal. Chim. Aaa, 582, 235-242. [Pg.977]

A computer-assisted system for predicting retention of aromatic compounds has been investigated in reversed-phase liquid chromatography. The basic retention descriptions have been derived from the studies on quantitative structure-retention relationships. The system was constructed on a 16-bit microcomputer and then evaluated by comparing the retention data between measured and predicted values. The excellent agreement between both values were observed on an octadecyl-silioa stationsu y phase with acetonitrile and methanol aqueous mobile phase systems. This system has been modified to give us the information for optimal separation conditions in reversed-phase separation mode. The approach could also work well for any other reveraed— phase stationsury phases such as octyl, phenyl and ethyl silicas. [Pg.167]

The simplest model phase in reversed-phase liquid chromatography (see Section 6.5) was not satisfactory for the quantitative analysis of the retention behavior of benzoic acid derivatives in silica. Therefore, several model phases were constructed and the energy values of their optimized structures were calculated using the MM2 program. The chromatographic retention data from ref. are listed in Table 6.8. [Pg.132]

M.-M. Hsieh and J.G. Dorsey. Accurate determination of log in reversed-phase liquid chromatography. Implications for quantitative structure-retention relationships. Journal of... [Pg.306]

M. M. Hsieh and j. G. Dorsey, J. Chromatogr., 631, 63 (1993). Accurate Determination of Log in Reversed-Phase Liquid Chromatography. Implications for Quantitative Structure-Retention Relationships. [Pg.304]