Q-TOFMS

Postmortem human brain AD patients (n=15) and control subjects (n=15). Validation set (n = 60) Metabolic fingerprinting UHPLC- Q/TOFMS (86)... 

Detection methods HPLC-DAD, HPLC with diode-array detection. HPLC-(ESI-MS), HPLC with electrospray ionization mass spectrometry. RP-HPLC, revcrsed-phase HPLC. UPLC/Q-TOFMS, UPLC with quadrupole-time of flight mass spectrometry. HPLC-APCI-MS, HPLC with atmospheric pressure chemical ionization mass spectrometry. CE-IT-MS, capillary elecliophoresis-ion-1r mass spectrometry. LC-ESI-ITMS, liquid chromatography-electrospray ionization ion trap mass spectrometry. LC-ELSD, LC with evaporative light scattering detector. DNBZ-Cl, 3,5-dinitrobenzoyl chloride. 

A next step in the development of LC-MS approaches in STA or GUS has been the use of two-stage, Q-TOFMS instruments able to generate accurate mass data of the parent as well as fragment ions directly attributable to the parent (21). 

Trends in MALDI-ToFMS research are search for new matrices, solvent-free sample preparation, advances in analyser design (oaToF-MS, Q-ToFMS, QITMS, QIT-ToF, ToF-ToF), and (on-line) coupling to other (pre)separation techniques. 

MALDI-Fourier transform ion cyclotron resonance mass spectrometry MALDI-Q-ion mobility-TOFMS MALDI-Quadrupole-ion-trap-TOF mass spectrometry MALDI-TOF-imaging mass spectrometry MALDI Time-of-flight mass spectrometry Magnetic resonance imaging Matrix solution fixation Moxifloxacin... 

The MALDI-MS instrumentation used for IMS included MALDI-TOF, MALDI-Q-TOF, MALDI-TOF-TOF, MALDI-Q-Ion Mobility-TOFMS (MALDI-Q-IM-TOFMS) [113-117], MALDI-FT-ICR-MS, MALDI-Ion Trap [73, 118-120], and MALDI-QIT-TOF [121],... 

J. R. Encinar, L. Ouerdane, W. Buchmann, J. Tortajada, R. Lobinski, J. Szpunar, IdentiPcation of water-soluble selenium-containing proteins in selenized yeast by size exclusion reversed phase HPLC-ICP-MS followed by MALDI-TOFMS and ESI-Q-TOF MS, Anal. Chem., 75 (2003), 3765D3774. 

Thin films of polyPCN (PPCN) and poly TDCN (PTDCN) for electrical activity tests were prepared by the ionized cluster beam-time-of-flight mass spectrometer (ICB-TOFMS) deposition method [23] (see also the chapters by Z. Q. Xue and H. J. Gao in this book). 

FIGURE 7.18 Time-of-flight mass spectra obtained with the reflectron ICP-TOFMS (1000-shot average) for pulsed ion injection utilizing (a) the Q, poles (4-ppm solution of Pb and Bi) and (b) poles (40-ppm solution of Pb and Bi). (Reprinted with permission from reference 29). 

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