Pyrvinium salts

A wide variety of pyrvinium salts (1) have been prepared by treating a quinoline quaternary salt (41) with 2,5-dimethyl-l-phenylpyrrole-3-carboxaldehyde (40) [42,43]. The latter is obtained by a Paal-Knorr synthesis starting with 2,5-hex-anedione (37) and aniline [44,45] (Scheme 1). 

High molecular weight quaternary salts such as bephenium hydroxynaphthoate (XXI) and pyrvinium embonate (XXII), being quaternary, have low lipid solubility but also have... 

Pyrantel, as pyrvinium, is available as the extremely insoluble and nonabsorbed pamoic acid salt one oral dose cures pinworm and Ascaris infections. It is curious that whipworm and threadworm infections do not respond. The drug acts as a depolarizing neuromuscular blocking agent (Chapter 8) on worms, which are then paralyzed. In Ascaris muscle strips it is 100 times more active than acetylcholine. 

Synonyms 6-(Dimethylaraino)-2-[2-(2,5-dimethy1-1-phenyl-lH-pyrrol-3-yl)ethenyl]-l-methylquinolinium salt with 4,4 -methylenebis-[3-hydroxy-2-naphthalenecarboxylie acid](2 l) pyrvinium embonate Trade names Povan Filmseals... 

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