Pyrimidinone, 4-amino-1-

Cytidine 2(1H)-pyrimidinone, 4-amino-1- 3-D-ribofuranosyl- 429b, 4249, 4554a ... 

Chemical Name 4-amino-1(3-D-arabinofuranosyl-2(1H)-pyrimidinone hydrochloride Common Name (3-cytosine arabinoside Structural Formula ... 

C,4H]3N0 42771-78-8) see Flurbiprofen 2-acetylamino-6-chloro-5-nitro-4(31/)-pyrimidinone (C9HJCIN4O4 51471-45-5) see Abacavir iV-acetyl-4-amino-2,4-dideoxy-2,3-didehydroneuraminic acid... 

Diacetylcyclopropane reacts with 3-amino-l, 2,4-triazole in acetic acid (either aqueous or glacial) to give triazolopyrimidines 28 <%1ZV1322>, whilst a selection of fiised-ring pyrimidines, for example the l,2,3-triazolo[4,S-prepared using amino hetmoarenecarboxamides and esters <96H(42)691 >. 

Ci0HuN4O6 H20 4-Amino-l-(4-amino-4-deoxy-/ -D-glucopyranosyl-uronic acid)-2( 1 H)-pyrimidinone, monohydrate (GOUGERIO)200... 

US patent 6,723,728, Polymorphic and other crystalline forms cis-FTC [106], The present invention relates to polymorphic and other crystalline forms of (—)-and ( )-cA-(4-amino-5-fluoro-l-(2-(hydroxymethyl)-l,3-oxathiolan-5-yl)-2(lH)-pyrimidinone, or FTC) [106]. Solid phases of (—)-cz>FTC that were designated as amorphous (—)-FTC, and Forms II and III were found to be distinguishable from Form I by X-ray powder diffraction, thermal analysis properties, and their methods of manufacture. A hydrated crystalline form of ( )-cA-FTC and a dehydrated form of the hydrate, were also disclosed, and can similarly be distinguished from other forms of FTC by X-ray powder diffraction, thermal properties, and their methods of manufacture. These FTC forms can be used in the manufacture of other forms of FTC, or as active ingredients in pharmaceutical compositions. Particularly preferred uses of these forms are in the treatment of HIV or hepatitis B. 

The reaction of 3-amino-2-hydrazino-4(3// )-pyrimidinones 234 with dimethyl acetylenedicarboxylate gave pyrimidinylidene hydrazones 236... 

Synthesis of Enantiomerically Pure p-Amino Acid from 2-tert-Butyl-1-carbomethoxy-2,3-dihydro-4(1 H)-pyrimidinone (S)-p-Tyrosine-O-methyl Ether. 

Significant contribution in the studying of the MCRs based on aminoazoles, aldehydes, and Meldrum s acid was made by Lipson and co-authors in their publications [ 114—119]. It was established that in some cases these multicomponent treatments can yield positional isomers. For example, refluxing of 3-amino-l,2,4-triazole with aldehydes and Meldrum s acid gave only triazolopyrimidinones 82 [114] (Scheme 36). On the other hand, MCRs involving 3-amino-5-methylthio-1,2,4-triazoles in boiling DMF yielded solely 5-pyrimidinones 83, while the... 

Electron-donating substituents also activate pyrimidinones toward nitration, and 2-amino-6-chloro-4(3//)-pyrimi-dinone 36 is readily nitrated with potassium nitrate in concentrated sulfuric acid at room temperature <2001TL1793>. However, care must be taken to avoid prolonged reaction which leads to hydrolysis of the chlorine atom, which is then followed by a second nitration and a subsequent ring-opening step <2001TL1793>. 

---