Pyrimethamine Zidovudine

INTERFERON ZIDOVUDINE t adverse effects with zidovudine Additive toxicity Monitor FBC and renal function closely. 1 doses as necessary. Use of pyrimethamine as prophylaxis seems to be tolerated... [Pg.375]

FIGURE 107 Patients with a clinical diagnosis of AIDS should undergo long-term therapy with zidovudine (AZT, 1200 mg q. 4 hrs). Acyclovir may potentiate the beneficial effects of AZT. In addition, patients should be treated prophylactically for Pneumocystis carinii pneumonia such regimens include sulfadoxine and pyrimethamine (Fansidar), dapsone, or aerosolized pentamidine. Dextran sulfate is also useful because it blocks the binding of HIV to target cells. [Pg.741]

Zidovudine (200 mg every 4 hours) is indicated in the management of patients with HIV infection who show evidence of impaired immunity. Trimethoprim-sulfamethoxazole, pyrimethamine, and acyclovir may be necessary for the management or prevention of opportunistic infections. Zidovudine (3 -azido-3 -deoxythymidine, commonly referred to as AZT) is a thymidine analog with antiviral activity against HIV-1, HIV-2, human T-lymphotropic (or leukemia) virus (HTLV)-I, and other retroviruses. Low concentrations (<0.001 to 0.04 pg/ml) inhibit acute HIV-1 infection in human T-cell lines and peripheral blood lymphocytes. Zidovudine is less active in human monocyte-macrophages or quiescent cells but inhibits HIV replication in human brain macrophages. Zidovudine is also inhibitory for HBV and EBV... [Pg.742]

Noninterfering acetaminophen, amphotericin B, brotizolam, ceftazidime, ciprofloxacin, codeine, diclofenac, didanosine, domperidone, fluoxetine, foscarnet, gangiclovir, methadone, metoclopramide, mianserin, nystatin, pyrimethamine, ranitidine, sulfamethoxazole, temazepam, trimethoprim, zidovudine... [Pg.617]

Pyrimethamine does not appear to alter zidovudine pharmacokinetics, and zidovudine does not appear to alter the prophylactic efficacy of sulfadoxine/pyrimethamine for toxoplasmosis. The combination of pyrimethamine and zidovudine may increase the risk of myelosuppression. [Pg.239]

The addition of pyrimethamine (200 mg loading dose then 50 mg daily) and folinie aeid 10 mg daily to zidovudine had no effeet on zidovudine pharmaeokineties, based on data from 10 HIV positive patients for whom zidovudine pharmaeokineties were available before and after starting pyrimethamine. Of 26 patients reeeiving the eombination, 5 developed leu-copenia and one diseontinued treatment beeause of anaemia. ... [Pg.239]

A study in patients with AIDS found that zidovudine 250 mg four times daily did not adversely affeet the prevention of toxoplasma eneephalitis with pyrimethamine/sulfadoxine (Fansidar), one tablet twice weekly for up to 8 months. /w vitro and animal data have shown that the combination of zidovudine and pyrimethamine caused synergistic decreases in lymphocyte and neutrophil numbers. ... [Pg.239]

The manufacturers of pyrimethamine note that the concurrent use of zidovudine may increase the risk of bone marrow depression. They say that if signs of folate deficiency develop, then pyrimethamine should be discontinued and folinie acid given. Note that the prophylactic use of a folate supplement, preferably folinie acid, is recommended for all patients with toxoplasmosis taking high-dose pyrimethamine, to reduce the risk of bone marrow suppression. See also NRTIs Zidovudine + Myelosup-pressive drugs , p.809... [Pg.239]

Freund YR, Dabbs J, Creek MR, HtilUps SJ, Tyson CA MacGregor JT. S3 rgistic bone marrow toxicity of pyrimethamine and zidovudine in murine in vivo and in vitro models mechanism of toxicity. Toxicol Appl PharmacolQBOT) 181,16-26. [Pg.239]

Simultaneous didanosine, folic acid, ganciclovir, lamivudine, nevirapine, pyrazinamide, ranitidine, rifampin, stavudine, sulfamethoxazole, trimethoprim, zidovudine Noninterfering adefovir, amprenavir, delavirdine, efavirenz, fluconazole, indinavir, itraconazole, methadone, nelfinavir, oxazepam, pyrimethamine, rifampin, ritonavir, saquinavir, zalcitabine... [Pg.2]

Noninterfering acetaminophen, amineptine, amphotericin B, aspirin, bromazepam, buspirone, citalopram, clobazam, diazepam, didanosine, fluconazole, flunitrazepam, flu-voxamine, hydroxyitraconazole, isoniazid, itraconazole, lamivudine, loprazolam, lora-zepam, metronidazole, minalcipram, nordiazepam, omeprazole, paroxetine, pyrimethamine, rifampin, sertraline, stavudine, sulfadiazine, trimethoprim, venlafaxine, zal-citabine, zidovudine, zolpidem, zopiclone... [Pg.38]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...