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Pyridoxine deficiency antibody response

Table I summarizes the effects of the various deficiencies of the vitamin B complex upon the response to a variety of antigenic stimuli in different test animals. It is the reviewers opinion that, with the exception of the criticisms already made, this table represents the results of well-controlled, adequate experiments. It is quite apparent that the individual members of the vitamin B complex play a very important role in determining antibody response. Their absence may produce a marked impairment in antibody production. Generalizations on this subject are dangerous, but it would appear that pyridoxine, pantothenic acid, and folic acid deficiencies show the most consistent deleterious effects upon antibody production. It is also apparent that the effects of the individual deficiencies may vary widely depending upon the antigen employed. Table I summarizes the effects of the various deficiencies of the vitamin B complex upon the response to a variety of antigenic stimuli in different test animals. It is the reviewers opinion that, with the exception of the criticisms already made, this table represents the results of well-controlled, adequate experiments. It is quite apparent that the individual members of the vitamin B complex play a very important role in determining antibody response. Their absence may produce a marked impairment in antibody production. Generalizations on this subject are dangerous, but it would appear that pyridoxine, pantothenic acid, and folic acid deficiencies show the most consistent deleterious effects upon antibody production. It is also apparent that the effects of the individual deficiencies may vary widely depending upon the antigen employed.
Figure 1. Effect of Repeated Antigenic Stimuli upon Antibody Response in Pyridoxine-deficient and Control Rats. Injections of Diphtheria Toxoid Given at Times Indicated by the Arrows. Animals were Fed the Pyridoxine-deficient or the Control Diet during the Entire Course of the Study, and were on Experiment for Four Weeks Prior to the First Toxoid Injection, Figures on the Ordinate Represent Reciprocal Titers. Used by Permission, from Axelrod (1958), Copyright by the American Society for Clinical Nutrition, Inc,... Figure 1. Effect of Repeated Antigenic Stimuli upon Antibody Response in Pyridoxine-deficient and Control Rats. Injections of Diphtheria Toxoid Given at Times Indicated by the Arrows. Animals were Fed the Pyridoxine-deficient or the Control Diet during the Entire Course of the Study, and were on Experiment for Four Weeks Prior to the First Toxoid Injection, Figures on the Ordinate Represent Reciprocal Titers. Used by Permission, from Axelrod (1958), Copyright by the American Society for Clinical Nutrition, Inc,...
Effect of Pyridoxine-deficiency upon Circulating Antibody Response to Alum-precipated Diphtheria Toxoid ... [Pg.96]

The development of a method suitable for the study of antibody synthesis by individual cells has facilitated investigations of antibody synthesis at the cellular level (Jerne and Nordin, 1963). With this procedure, we have demonstrated a dramatic reduction in the number of antibody-forming cells in the spleens of pyridoxine-deficient rats immunized with sheep erythrocytes (Figure 6) (Kumar and Axelrod, 1968). This decreased cellular immune response was independent of the inanition associated with the deficiency and was... [Pg.101]

See other pages where Pyridoxine deficiency antibody response is mentioned: [Pg.148]    [Pg.71]    [Pg.4]    [Pg.5]    [Pg.6]    [Pg.7]    [Pg.7]    [Pg.8]    [Pg.10]    [Pg.11]    [Pg.19]    [Pg.22]    [Pg.94]    [Pg.96]    [Pg.101]    [Pg.102]    [Pg.103]    [Pg.7]   
See also in sourсe #XX -- [ Pg.93 , Pg.96 ]



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