Pyridine dicarboxylate

Pyridine 210 is oxidized by 20% nitric acid at the acetyl group to 2-methyl-5-pyridinecarboxylic acid, while its ozonation gives cinchomeronic acid [pyridine-2,5-dicarboxylic acid (215)] (75DIS) which is decarboxylated (200°C, 2 h) to nicotinic acid 216 in 97% yield (75DIS). 

Cyclohexaamylose continued) mono-6-O-tosyl-, preparation of, 23 250 pyridine-2,5-dicarboxylic acid derivative, catalytic action of, 23 251 separation of, by complexing, 23 214 structure, stereochemistry and physical properties of, 23 210-213... 

Reaction of the m-nitrophenyl ester of pyridine-2,5-dicarboxylic acid with cyclodextrin (see Section 3) gives a picolinate ester [52] of a cyclodextrin secondary hydroxyl group (Breslow, 1971 Breslow and Overman, 1970) which will bind metal ions or a metal ion-pyridine carboxaldoxime complex. Such a complex will catalyse hydrolysis of p-nitrophenyl acetate bound within the cyclodextrin cavity leading to a rate constant approximately 2000-fold greater at... 

Pyridine-2,5-dicarboxylic acid [100-26-5] M 167.1, m 254 . Crystd from dilute HCI. Pyridine-2,6-dicarboxylic acid see dipicolinic acid. 

The problem was resolved essentially by stepwise degradation of the molecule to furan-3-carboxylic acid, pyridine-2,5-dicarboxylic acid (V), nupharidinic acid (XVIII), and anhydronupharanediol, C15H30O (XV), with the structure of the last-named supplying the key to that of deoxynupharidine (15, 16). Chart I show s the main steps of the degradation. 

When dehydrogenated on palladium the hexahydroderivative IV afforded C15H23ON which could be converted to pyridine-2,5-dicarboxylic acid (V) by oxidation with permanganate (13, 18, 19). 

Pyridine-2,5-dicarboxylic acid (isocinchomeronic acid) (C H.O.N) 700M... 

Pyridinedicarboxylic acid CAS 100-26-5 EINECS/ELINCS 202-834-2 Synonyms Isocinchomeronic acid 2,5-Pyridinedicarboxylic acid Pyridine-2,5-dicarboxylic acid Classification Organic compd. 

---