L- pyrazoles

Oxidation of N -substituted pyrazoles to 2-substituted pyrazole-l-oxides using various peracids (30) facilitates the introduction of halogen at C, followed by selective nitration at C. The halogen atom at or is easily removed by sodium sulfite and acts as a protecting group. Formaldehyde was... [Pg.311]

Methylpyrazole has been investigated as a possible treatment for alcoholism. The stmcture—activity relationship (SAR) associated with a series of pyrazoles has been examined ia a 1992 study (51). These compounds were designed as nonprostanoid prostacyclin mimetics to inhibit human platelet aggregation. In this study, 3,4,5-triphenylpyrazole was linked to a number of alkanoic acids, esters, and amides. From the many compounds synthesized, triphenyl-IJT-pyrazole-l-nonanoic acid (80) was found to be the most efficacious candidate (IC g = 0.4 //M). [Pg.317]

Niai) Dimethylbis(pyrazol-l-yl)gallate [GaMe2(Pz)2] Ni[GaMe2(Pz)2]2 75JCS(D)176 ... [Pg.227]

Nitration of 4-(2-thienyl)- (301) and 4-(3-thienyl)-pyrazoles (302) mainly occurs on the thiophene ring, but when acetyl nitrate is used as the nitration agent small quantities of products nitrated on the pyrazole ring are isolated (position of the nitro group uncertain) (80CS( 15)102). Pyrazol-l -ylpyridines (303) undergo electrophilic reactions (bromination, chlorination and nitration) preferentially in the pyrazole ring. Thus, the nitration of (303 R = R = = H) either with a mixture of nitric acid and sulfuric acid at 10-15 °C or with... [Pg.238]

L-jS-Pyrazolylalanine (755) and y-L-glutamyl-/8-pyrazol-L-alanine are found in the seeds of many speeies of Cucurbitaceae (65P933). It was subsequently demonstrated that free pyrazole oeeurs in watermelon seeds in eoneentrations of 280 to 410 jLg g depending on the variety (75P2512). Biosynthetic studies implieate 1,3-diaminopropane as a precursor of the pyrazole moiety of (755) (82P863). [Pg.303]

Pyrazole, l,3-dimethyl-5-phenyl- H NMR, 5, 186 (B-73NMR165, B-76MI40402) Pyrazole, l,5-dimethyl-3-phenyl- H NMR, 5, 186 (B-73NMR165, B-76MI40402) Pyrazole, 3,5-dimethyl-1-phenyl- N NMR, 5, 196 <80OMR(13)97>... [Pg.46]

Phosphetanium tetrachloroaluminum salt, 1-chloro-2,2,3-trimethyl-1-phenyl-synthesis, 1, 524 Phosphindole synthesis, 1, 517 Phosphine, pyrazol-l-yl-synthesis, 5, 236 Phosphirane, 1-phenyl-synthesis, 1, 525 Phosphirane, 1,2,3-tri-t-butyl-... [Pg.743]

Poly(phenylenepyrazoles), 5, 300 Polypyrazoles, 5, 300 N-substituted, 5, 300 Polypyrazolines, 5, 300 Poly(pyrazol-l-yl) borates as ligands, 5, 225, 235 Polypyrroles applications, 4, 376 Polypyrrole tetrafluoroborate conductors, 1, 355 Polysaccharides as pharmaceuticals, 1, 152 Poly-2,5-selenienylenes applications, 4, 971 Polysilacyclopentanes, 1, 609 Polysufides macrocyclic... [Pg.748]

Pyrazole, 3-ethoxycarbonyl-3 (5 ),5-dimethyl-5 (3 )-pyrazol-l-yl-reduction, 5, 260 Pyrazole, ethynyl-reactions, 5, 261 Pyrazole, 4-formyl-IR spectra, S, 201 NMR... [Pg.771]

Pyrazole, 1 -(2-methylaminophenyl)-synthesis, 5, 283 Pyrazole, l-methyl-5-nitro-2-oxide... [Pg.772]

Study on poly(pyrazol-l-yl)alkane complexes 99MI32. [Pg.252]

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