Pyrazinamide drug interactions

Rifabutin appears as effective as rifampin in the treatment of drug-susceptible tuberculosis and is used in the treatment of latent tuberculosis infection either alone or in combination with pyrazinamide. Clinical use of rifabutin has increased in recent years, especially in the treatment of HIV infection. It is a less potent inducer of cytochrome 450 enzymes pathways than rifampin and results in less drug interaction with the protease inhibitors and nonnucleoside reverse transcriptase inhibitors. Rifabutin is therefore commonly substituted for rifampin in the treatment of tuberculosis in HIV-infected patients. Another important use of rifabutin in the HIV-infected population is prevention and treatment of disseminated MAC. 

Drug-Drug interaction A study evaluating the safety of co-adnxinistration of TDF, EFV and FTC with TB treatment (rifampicin, isoniazid, pyrazinamide and ethambutol) found slightly higher AUCo-24 for three agents when... 

Drug/Lab test interactions Pyrazinamide has been reported to interfere with Acetest and Ketostix urine tests to produce a pink-brown color. 

The major problem in tuberculosis therapy is the buildup of resistance to the drug in use. Attempts at overcoming this difficulty took the form of additives such as substituted phenothiazines and acridines to retard emergence of resistance to INH 3i qj, combinations of drugs such as INH plus ethionamide, pyrazinamide, cycloserine or ethoxide . The biophysical aspects of the interaction of amino acridines with nucleic acids were reviewed 3,... 

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