PWWP domain

PWWP domain with conserved PWWP motif E(MFP) 2(2) 1(1) ... 

Qiu, C., Sawada, K., Zhang, X. and Cheng, X. (2002) The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nature Structural Biology, 9, 217-224. 

The specific domains that recognize KMe have been described within several protein families the so-called "royal family" of Tudor, Agenet, chromo, PWWP, and MBT domains the plant homeodomain (PHD) the WD40 repeat protein—WDR5 and ankyrin repeats [37,38]. Given the rapid rate of progress in this area, the relatively low affinity of these interactions (Kd values typically 10-100 jjM), the wide variety of... 

Maurer-Stroh, S., Dickens, N.J., Hughes-Davies, L., Kouzarides, T., Eisenhaber, F. and Ponting, C.P. (2003) The Tudor domain Royal Family Tudor, plant Agenet, Chromo, PWWP and MBT domains. Trends in Biochemical Sciences, 28, 69-74. 

LEDGF/p75 is a 530 amino acid protein consisting of two major functional domains (Fig. 12). The first 300 amino acids make up the chromatin binding portion of the protein which includes a PWWP chromatin recognition sequence,... 

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