PUVA, malignant melanoma

PUVA, malignant melanoma, 22.166 Pyrazinamide, in latent pulmonary tuberculosis, 27.323... 

Stern RS Nichols KT, Vakeva LH. Malignant melanoma in patients treated for psoriasis with methoxsalen (psoralen) and ultraviolet A radiation (PUVA). The PUVA Follow-Up Study. N Engl J Med 1997 336(15) 1041-5. 

Although PUVA is apparently not responsible for any increased incidence of internal malignancy, risk benefit considerations with regard to melanoma and nonmelanoma skin cancers indicate an increased risk for melanoma, but no increase for nonmelanoma skin cancers, according to some authors, despite development of increased numbers of lentigines. Other investigators report an increased incidence of nonmelanoma skin cancers in association with PUVA. ... 

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