Purinethol - Mercaptopurine

Arimidex - anastrozole Hexalen - altretamine Purinethol- mercaptopurine... 

Purinethol mercaptopurine. puromycin ban, inn, usan] (puromycin hydrochloride [USAN] NSC 3055 CL 16536 antibiotic CL 16536 CL 13900 3123L P 638 antibiotic CL 13900 antibiotic 3123L antibiotic P 638) is a nucleoside-type ANTIBIOTIC isolated from Streptomyces alboniger. It has anticancer and ANTITRYPANOSOMAL activity, puromycin hydrochloride puromycin. p-xylotocopherol p-tocopherol. 

Let s start with three examples of antitumor drugs that work by the inhibition of DNA synthesis methotrexate (MTX, Methopterin), 5-fluorouracil (Fluril), and 6-mercaptopurine (Purinethol). These are all old cancer drags, marketed under numerous trade names, including those indicated above. Although the mechanism of action of each one is different, at the end of the day they all inhibit DNA synthesis. 

Mercaptopurine [6-MP] (Purinethol) [Antineoplastic/ Antimeta lite] Uses Acute leukemias, 2nd-line Rx of CML NHL, maint ALL in children, immunosuppressant w/ autoimmune Dzs (Crohn Dz) Action Antimetabolite, mimics hypoxanthine Dose Adults. 80-100 mg/mVd or 2.5-5 mg/kg/d maint 1.5-2.5 mg/kg/d Peds. Per protocol X w/ renal/hepatic insuff on empty stomach Caution [D, ] Contra Severe hepatic Dz, BM suppression, PRG Disp Tabs SE Mild hematotox, mucositis, stomatitis, D rash, fever, eosinophilia, jaundice. Hep Interactions T Effects W/ allopurinol T risk of BM suppression W/ trimethoprim-sulfamethoxazole X effects OF warfarin EMS May falsely T glucose OD May cause NA and liver necrosis symptomatic and supportive Meropenem (Merrem) [Antibiotic/Carbapenem] Uses lntra-abd Infxns, bacterial meningitis Action Carbapenem X cell wall synth, a [3-lactam Dose Adults. 1 to 2 g IV q8h Peds. >3 mo, <50 kg 10-40 mg/kg IV q 8h in renal insuff Caution [B, ] Contra [3-Lactam sensitivity Disp Inj 500 mg, 1 g SE Less Sz potential than imipenem D, thrombocytopenia Interactions T Effects W/ probenecid EMS Monitor for signs of electrolyte disturbances and... 

Mercaptopurine Purinethol Acute lymphocytic and myelocytic leukemia chronic myelocytic leukemia Blood disorders (anemia, leukopenia, thrombocytopenia] Gl distress (nausea, loss of appetite] hepatotoxicity... 

A variety of other agents with cytotoxic effects has been used to suppress the immune system. These drugs include chlorambucil (Leukeran), dactinomycin (Cosmegen), mercaptopurine (Purinethol), vinblastine (Velban), and vincristine (Oncovin, Vincasar).41 These... 

Azathioprine (3 to 10 mg/kg) prevents transplant rejection. It is reserved for patients deemed unresponsive to cyclosporine and prednisone. Azathioprine is cleared to 6-mercaptopurine, which in turn can be converted to 6-mercaptopurine nucleotides leading to an inhibition of de novo purine synthesis or anabolism to thio-IMP, which, as a fraudulent nucleotide, can interfere with the salvage pathway of purine synthesis. Thio-IMP is subsequently converted to thio-GMP and eventually thio-GTP, leading to DNA damage upon intercalation of thio-GMP into the DNA backbone (see Figure 28). Azathioprine is a more effective immunosuppressant than is mercaptopurine (Purinethol). 

Purinethol (Gertrude Belle EUon) Ehon develops the first effective treatment for childhood leukemia, 6-mercaptopurine (Purinethol). Ehon later discovers azathioprine (Imuran), an immunosuppressive agent used for oi n transplants. 

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