Purines structural aspects

Structural Aspects of Pt-Purine Interactions From Models to DNA... 

This important aspect of purine structure is still of active interest. Theoretical and practical studies have been carried out to ascertain the site of... 

Moorthy PN, Hayon E (1975) Free-radical intermediates produced from the one-electron reduction of purine, adenine and guanine derivatives in water. J Am Chem Soc 97 3345-3350 Mori M, Teshima S-l, Yoshimoto H, Fujita S-l, Taniguchi R, Hatta H, Nishimoto S-l (2001) OH Radical reaction of 5-substituted uracils pulse radiolysis and product studies of a common redox-ambivalent radical produced by elimination of the 5-substituents. J Phys Chem B 105 2070-2078 Morin B, Cadet J (1995) Chemical aspects of the benzophenone-photosensitized formation of two lysine - 2 -deoxyguanosine cross-links. J Am Chem Soc 117 12408-12415 Morita H, Kwiatkowski JS,TempczykA(1981) Electronic structures of uracil and its anions. Bull Chem Soc Jpn 54 1797-1801... 

For recent reviews of the chemistry of the nucleic acids and related topics see B. Lythgoe, Chemistry of Nucleosides and Nucleotides, Ann. Repts. on Progress Chem. (Chem. Soc. London), 41, 200 (1945) R. S. Tipson, The Chemistry of the Nucleic Acids, Advances in Carbohydrate Chemistry, 1, 193 (1945) A. R. Todd, Synthesis in the Study of Nucleotides, J. Chem. Soc., 647 (1946) B. Lythgoe, Chemistry of Adenine Nucleotide Coenzymes, Ann. Repts. on Progress Chem. (Chem. See. London), 42, 175 (1946) B. Lythgoe and A. R. Todd, Structure and Synthesis of Nucleotides, Symposia Soc. Expll. Biol. I. Nucleic Acid, 1947, 15 A. R. Todd, Synthase de Nucleotides, Bull. soc. chim. France, 1948,933 B. Lythgoe, Some Aspects of Pyrimidine and Purine Chemistry," Quart. Revs., 3, 181 (1949). 

In this chapter, we have reviewed some of our own work on solvation properties in supercritical fluids using molecular dynamics computer simulations. We have presented the main aspects associated with the solvation structures of purine alkaloids in CO2 under different supercritical conditions and in the presence of ethanol as co-solvent, highlighting the phenomena of solvent density augmentation in the immediate neighborhood of the solute and the effects from the strong preferential solvation by the polar co-solvent. We have also presented a summary of our results for the structure and dynamics of supercritical water and ammonia, focusing on the dielectric behavior of supercritical water as functions of density and temperature and the behavior of excess solvated electrons in aqueous and non-aqueous associative environments. 

Co11 complexes of imidazole retain some interest as structural models for biological systems, notably carboxypeptidase A and thermolysin. Vallee and colleagues discuss this with special reference to MCD spectra,322 and Hodgson discusses stereochemical aspects of purine and metal-nucleotide complexes for similar reasons.323 Horrocks, Ishley and Whittle have recently described some [Co(02CR)2(im)2] structural models, e.g. (61), which have physical properties similar to Co"-substituted carboxypeptidase.324... 

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