Pulmonary drug delivery dissolution rate

Pharmaceutically viable formulation applications include topical, pulmonary, depot and implantable drug delivery systems (Bhardwaj and Blanchard, 1996 Cleland andjones, 1996 Schwendeman etal., 1996 Johnsonetal., 1997 Schwendeman et al., 1997 Carrasquillo et al., 1999 Stevenson et al., 1999 Wright et al., 2001 Kikwai et al., 2004). Simple depot formulations, designed to decrease dissolution rates, have used non-aqueous conditions to achieve controlled release. Growth hormone has also been suspended in oil for depot injections (Yu et al., 1996). 

As excipients, CDs have been widely used to cover the bitter taste of drugs, to increase their dissolution rates, to reduce irritation reactions and in low concentrations to suppress the haemolysis induced by some drugs [180]. Great effort has been made to develop CD-based drug formulations with different administrative routes, including parenteral, oral, pulmonary, nasal [181], transdermal, rectal [182] and ophthalmic [183] drug delivery [184]. 

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