Pteroylglutamic acid synthesis

Folic acid (foladn) Pteroylglutamic acid-containing coenzymes Nucleic acid synthesis, protein metabolism... 

Folate (pteroylglutamic acid) is essential for the synthesis and methylation of DNA during fetal and early postnatal development (Nunn et al., 1986). Folate deficiency may result from poor diet, malabsorption, from treatment with anticonvulsant drugs such as phenytoin or primidone, as well as from antifolate drugs such as methotrexate. Folate deficiency during pregnancy leads to an increased prevalence of fetal malformations such as spina bifida and related neural tube defects. Findings... 

One of the first studies that indicated the possible interference of ametbopterin and aminopterin with purine synthesis was the demonstration by Skipper et al. (S21) that administration of these compounds to mice inhibited the incorporation of labeled formate into nucleic acid purines. Ametbopterin (4-amino-A -methyl-pteroylglutamic acid) has produced some inhibition of uric acid synthesis during the use of this compound for treatment of leukemia (K15, E24). Another inhibitor of... 

Pteroylaspartic acid, IX, 133 antagonism to pteroylglutamic acid and its homologues, VI, 16, 17 Pteroyldiglutamic acid, synthesis of isomers of, VI, 15... 

Folic acid (pteroylglutamic acid) and related compounds are present at high concentration in liver, but spinach, broccoli, peanuts, and fresh fruit are also good dietary sources. The RDA is 300 pg. Folates are important for the synthesis of tetrahydrofolate which is important with cobalamin for a series of 1-carbon transfer reactions leading to DNA synthesis, failure of which leads to megaloblastic anemia. 

Therefore, there are two matters to consider in the biogene of folic acid and its biologically functional forms (o) the synthesis and breakdown of the pteroylglutamic acid molecule (6) the formation of the biologically functional forms of folic acid in cell metabolism. 

Pteroylglutamic Acid. The structure of vitamin B and of the L. casei factor was elucidated by a series of chemical degradations, the details of which are found in an article by Hutchings and Mowat (300). The structure established by chemical degradation (22,425) was confirmed by the synthesis of N-[4- ([2-amino-4-hydroxy-6-pteridyl]methyl) amino benzoyl]-L glutamic acid, pteroylglutamic acid (PGA), a substance identical to vitamin B, and to the fiver L. casei factor. 

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