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Pteroylglutamates

A concentrated pteroylglutamic acid (PGA) solution (1 mg/ml) is prepared with crystalline PGA dissolved in 20% (v/v) ethanol/water. The pH is adjusted with 0.1 N NaOH to pH 10-11 to dissolve the PGA, 0.06 N H2S04 is then used to readjust the pH to 7.0. Appropriate dilutions... [Pg.219]

Figure 15.2 Structural formula of tetrahydrofolate and representation of derivatives involved in single carbon transfer. The tetrahydrofolate is always part of a complex with several glutamate residues. The parent compound, pteroylglutamate (folate) lacks four hydrogen atoms, one each from carbon atoms 5, 6, 7 and 8. Tetrahydrofolate can exist in any one of three oxidation states, as shown they are interconvertible through oxidereduction reactions. Each plays a individual and different role is synthesis of key compounds (See below). Figure 15.2 Structural formula of tetrahydrofolate and representation of derivatives involved in single carbon transfer. The tetrahydrofolate is always part of a complex with several glutamate residues. The parent compound, pteroylglutamate (folate) lacks four hydrogen atoms, one each from carbon atoms 5, 6, 7 and 8. Tetrahydrofolate can exist in any one of three oxidation states, as shown they are interconvertible through oxidereduction reactions. Each plays a individual and different role is synthesis of key compounds (See below).
Folic Acid (Folacin Pteroylglutamic Acid Folate)... [Pg.62]

Folic acid (foladn) Pteroylglutamic acid-containing coenzymes Nucleic acid synthesis, protein metabolism... [Pg.780]

Parenteral 300 meg vials and prefilled syringes for IV or SC injection Folic acid (folacin, pteroylglutamic acid) (generic)... [Pg.751]

Amethopterin (Methotrexate, 4-amino-4-deoxy-Ar -methyIpteroyl-L-glutamic acid) [59-05-2] M 454.4, m 185-204°(dec), [a]p°+19° (c 2, 0.1N aq NaOH). Commonest impurities are 10-methyl pteroylglutamic acid, 4-amino-10-methylpteroylglutamic acid, aminopterin and pteroylglutamic acid. Purified by chromatography on Dowex-1 acetate, followed by filtration through a mixture of cellulose and... [Pg.463]

Studies on growth factors required by certain microorganisms, for example Streptococcus faecalis and Lactobacillus casei, and of their relevance in animal nutrition, led to the isolation and characterization of folic acid, pteroylglutamic acid (104), the structure of which was determined in 1946. It is an essential vitamin for man and together with vitamin B12 it is involved in the development of blood cells. Deficiency causes macrocytic anaemia. Many microorganisms do not use exogenous folic acid, but synthesize their own, and some... [Pg.160]

Pterin coenzymes such as folic acid (pteroylglutamic acid) and biopterin, which contain a dicyclic pteridine ring, a part of the skeleton of flavins, are also known to play versatile roles in biological redox reactions [67]. The oxidizing ability of the excited state of a pteridine derivative (lumazine [Lu])... [Pg.121]

Folic acid (folacin, pteroylglutamic acid) (generic)... [Pg.759]

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See also in sourсe #XX -- [ Pg.404 ]

See also in sourсe #XX -- [ Pg.162 ]



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Pteroylglutamate

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