Psychiatric disorder cannabinoids

Cannabinoids As the active ingredient in marijuana, Cannabinoids act on the cerebral cortex and are prescribed for cancer patients who do not respond to other antiemetics. Cannabinoids are contraindicated for patients who have glaucoma and psychiatric disorders. These include ... 

The history and science of cannabis and cannabinoids and their relation to mental health and disease are fraught with controversy, ambivalence, and contradictory claims. Perhaps this is inevitable when one considers that endocannabinoids serve a modulatory function in many neurochemical and psychopharmacological processes, and deficiencies or excesses in any of these may produce manifestations of psychopathology. The different aspects of this controversy regarding the role of caimabis in psychiatric disorders have been reviewed previously in detail... 

The cannabinoids act on the cerebral cortex and have the same side effects and adverse reactions as antihistamines and anticholinergic. These include drowsiness, dry mouth, blurred vision, tachycardia, and constipation. Caimabinoids include dronabinol and nabilone. These drugs should not be administered to glaucoma patients because they dilate the pupils (mydriasis). They are contraindicated for use in patients with psychiatric disorders and also used as an appetite stimulant for patients with AIDS. Side effects include mood changes, euphoria, drowsiness, dizziness, headaches, depersonalization, nightmares, confusion, incoordination, memoiy lapse, dry mouth, orthostatic hypotension, hypertension, and tachycardia. Less common symptoms include depression, anxiety, and manic psychosis. 

Since the cannabinoid agonists are not first-line drugs in the treatment of any of the various types of pain or pain syndromes, any potential risk of serious consequences from their use should be considered an absolute contraindication. Preexisting or genetic predisposition to serious psychiatric disorders such as schizophrenia or psychotic disorders, in general, would be an example. Precipitation or worsening of these and less serious psychiatric disorders has been reported. Caution and close monitoring of patients with less serious illnesses such as bipolar disorder, anxiety, or depression is necessary since the symptoms of these disorders could become manifest. 

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