Psoriatic-like dermatitis

Figure 7.6 Flaky skin mouse skin samples stained by a standard H E method. (A). The water-treated skin section shows marked hyperkeratosis, mild parakeratosis, modest acanthosis, elongated rete ridges, and modest dermal inflammation, consistent with psoriatic-like dermatitis. B. The water-GTE-treated skin section shows slight hyperkeratosis, no parakeratosis, mild acanthosis, no elongated rete ridges, and mild dermal inflammation (100x magnification).

Psoriatic lesions are relatively asymptomatic however, pruritus is a complaint in about 25% of patients. Severe, widespread psoriasis may involve symptomatology similar to that of exfoliative dermatitis, which may include fever and chills. Psoriatic arthritis is a distinct clinical entity in which both psoriatic lesions and inflammatory arthritis-like symptoms occur. Classically, distal interphalangeal joints and adjacent nails are involved, but knees, elbows, wrists and ankles also may be involved. 

Drugs like spantide II and ketoprofen, which are effective against allergic contact dermatitis and psoriatic plaque, can be transformed into nanogels by using hydroxypropyl methylcellulose (HPMC) and carbopol with the desired viscosity. BUayered nanoparticles from poly-(lactide-co-glycohc acid) and chitosan were prepared using surface modification with oleic acid. 

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