Psoralens antibacterial

Psoralea corylifolia L. Bu Gu Zi (Scuff pea) (fruit) Psoralen, angelicin, psoralidin, coryfolin, bavachinin, isobavachin, corylifolinin, d-backuchiol33 Coronary vasodilating effect, increase the myocardial contraction, antibacterial, anticancer. 

The photochemical activity (phototoxicity) of several psoralen derivatives has potential appU-cation in several areas. Biotin derviative (340), for example, is a neoplasm inhibitor it inhibited the growth of lymphocytes by 99% in the presence of near UV light <87MIP8705805). Compounds (341) and (342) both displayed photochemical antibacterial activity <87Mi 208-04). Benzopsoralen (343) is a DNA photoreagent <86JHCI405). 

The LFCs psoralen (79), xanthotoxin (81), bergapten (91) and isopimpinellin (93) (Figure 5.18) are antibacterial when combined with UV light (Beier etal. 1983a Manderfeld... 

An important application, recently developed, is represented by sterilizing blood components, in particular, platelet concentrate. Recently, clinical trials carried out with a novel psoralen S-59 derivative demonstrated the efficacy of the photochemical treatment, thus offering the potential to reduce transfusion-related viral and antibacterial diseases. 

---