Pseudomonas tabaci

Tabtoxin J is a dipeptide exotoxin produced by Pseudomonas tabaci, the organism responsible for the wildfire disease of tobacco plants [141]. When hydrolyzed by peptidase, in vivo, this exotoxin releases tabtoxinine-p-lactam K, which inhibits Glutamine synthetase of the photorespiratory nitrogen cycle, causing chlorosis and death of tobacco plants [142]. 

Rhizopus, Penicilliurn, Claviceps purpurea (with Secale cereale) Pseudomonas tabaci Pseudomonas aeruginosa Flustra foliacea... 

Tabtoxin is an exotoxin of the phytopathogenic bacterium Pseudomonas tabaci, first isolated in 1952, and induces the wildfire disease, a leaf-spot disease, on tobacco plants [41]. The structure of tabtoxin 27 was reported almost 20 years later [42],... 

Tabtoxin (D 23) Produced in Pseudomonas tabaci, originating wildfire disease of tobacco... 

Wild-fire toxin is produced by Pseudomonas tabaci, an organism which causes a leafspot disease in tobacco plants. The correct structure was determined by Stewart (2), and shown to be (241), although no assignment of stereochemistry was made. Wild-fire toxin is an unstable substance rapidly converted at neutral pH to isotabtoxin (242) by way of intramolecular attack of the amino-group on the 3-lactam. Hydrolysis of wildfire toxin gives threonine and tabtoxinine (243). 

Some plant pathogenic bacteria and their phytotoxins have been screened in bioassays that monitor the effects of their toxins (antibiotic and phytotoxic) on other sensitive bacteria. For example, several fluorescent Pseudomonas syringae pvs. produce extracellular phytotoxins.76,106,116 Tabtoxin is produced by P. syringae pv. tabaci and pv. coronafacines, and this natural product inhibits glutamine synthetase.34,46,116 Phaseolotoxin, produced by P. syringae pv. phaseolicola... 

Turner, J. G. and Taha, R. R. 1984. Contribution of tabtoxin to the pathogenicity of Pseudomonas syringae pv. tabaci. Physiol. Plant Pathol. 25, 55-69... 

The first really molecular study of phytotoxins was done at the Rockefeller Institute, starting in the late 1940 s by a physiologist-biochemist team, Braun and Woolley, who worked with Pseudomonas syringae pv. tabaci. This bacterium produces the so called wildfire toxin, the name coming from the rapidity with which chlorosis is induced by the pathogen producing toxin in the leaves of the natural host, tobacco. They proposed a structure for this toxin, and because of its presumed structural and physiological resemblances to methionine sulfoximine, a recently discovered compound that interfered with methionine metabolism, they hypothesized that wildfire toxin acted in a similar, if not identical, manner. 

Phytopathogenic Pseudomonas strains were the first organisms that exploited this Achilles heel of plants P. syringae pv tabaci produce the glutamine synthetase inhibitor tabtoximine-j8-lactam, which enables the pathogen to colonize the host tissue killed by the toxin. 

Some 50 years ago it was discovered that certain phytopathogenic Pseudomonas strains, namely P. syringae pv. tabaci, release a toxic metabolite at the site of leaf... 

Tabtoxin or wildfire toxin (12), produced by Pseudomonas syringae pv. tabaci and related bacteria, on tobacco pro-... 

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