Pseudoephedrine SSRIs

Clinically important, potentially hazardous interactions with aminophylline, ciprofloxacin, dextromethorphan, entacapone, fluoxetine, fluvoxamine, MAO inhibitors, meperidine, pethidine, pseudoephedrine, SSRIs... 

Many commonly used medications also contain substances that are eliminated by the MAOIs and must not be taken by these patients. The list of medications to be avoided inclndes the narcotic pain reliever meperidine (Demerol), and many over-the-connter cold remedies containing dextromethorphan or pseudoephedrine. Finally, patients taking MAOIs must also avoid medications that elevate serotonin levels. This inclndes certain appetite snppressants and antidepressants including the SSRIs, venlafaxine, duloxetine, mirtazapine, nefazodone, and trazodone. Medications that interact with the MAOIs cannot be taken until at least 2 weeks after the MAOI has been stopped. 

ASA = aspirin NSAIDs = non-steroidal anti-inflammatory drugs, such as ibuprofen, naproxen, and diclofenac CNS stimulants include drugs such as pseudoephedrine, dextroamphetamine, theophylline, and caffeine MAO = monoamine oxidase CNS depressants include drugs such as benzodiazepines, barbiturates, and ethanol SSRIs = selective serotonin reuptake inhibitors, such as fluoxetine, sertraline, and paroxetine. Antidiabetic agents include drugs such as insulin, glipizide, glyburide, and metformin. 

Adrenaline hypertension Anticoagulants, oral skin necrosis Antituberculosis drugs hepatotoxicity Pseudoephedrine toxic epidermal necrolysis SSRIs suicidal behavior Statins acute pancreatitis Ximelagatran liver damage... 

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