Pseudo-oligosaccharides

Potassium native gellan, 389-391,430-431 Pseudo-oligosaccharides, spirodioxanyl, 220-221 Pyramine... 

Aminoglycoside antibiotics represent a family of highly charged naturally occurring pseudo-oligosaccharides (Figure 10.2). The common core of most... 

Recently, pseudo-oligosaccharidic enzyme-inhibitors acarbose (3) [6], trestatins (4) [7], adiposins (5) [8], S-AI [9, 10], and oligostatins [11, 12] have been found in fermentation beers (Scheme 3, 4, 5). 

The methylacarviosin 447, a core structure of acarbose and related pseudo-oligosaccharidic a-amylase inhibitors, together with its 6-hydroxy analog 448, were prepared by Shibata et al. [257] from the corresponding oligobiosaminide derivatives 443 and 444. The aziridine intermediates 445 and 446 were treated with hydrochloric acid to give the corresponding 6 -chloro derivative, and then elimination of the chlorine by base fmnished the title compoimds 447 and 448 as peracetylated derivatives (compoimds 441-448). 

In a broader perspective a plethora of the alcoholic functions of the 1,3-diaminoinositol ie., the pharmacophoric moiety are strategically substituted via various glucosidic bonds studded with appropriate characteristic aminosugars to give rise to the production of pseudo-oligosaccharides. 

A number of amylase inhibitors have been reported these are proteins, glycoproteins or pseudo-oligosaccharides isolated originally from grains or microorganisms. Acarbose, Bay g 5421 is the most... 

J. M. Garcia Fernandez, C. O. Mellet, V. M. Diaz Perez, J. Fuentes, J. Kovacs, and I. Pinter, Synthesis of (1 -6)-carbodiimide-tethered pseudo oligosaccharides via aza-Wittig reaction, Carbohydr. Res, 304 (1997) 261-270. 

In another nice contribution the sialylation of cyclic pseudo-oligosaccharides, derived by click chemistry, by use of TcTS and MU-Neu5Ac were studied to give di- as well as tri-sialylated products. In all cases a-sialylation was obtained at all terminal Gal-3-positions (Fig. 7) [43]. 

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