Of pseudo-oligosaccharides

In a broader perspective a plethora of the alcoholic functions of the 1,3-diaminoinositol ie., the pharmacophoric moiety are strategically substituted via various glucosidic bonds studded with appropriate characteristic aminosugars to give rise to the production of pseudo-oligosaccharides. 

Aminoglycoside antibiotics represent a family of highly charged naturally occurring pseudo-oligosaccharides (Figure 10.2). The common core of most... 

Calculate the T, values for the carbonyl carbons of the oligosaccharide. Load the raw data of the pseudo 2D C T, inversion recovery experiment D NMRDATA OLIGOSAC 1D C OCT1 2D 001001.SER. Decompose the 2D data matrix into a series of 1D FIDs, process and plot them according to the recommendations given in previous chapters. Exploit the options for automatic and serial processing. Determine the T, values for the individual carbon nuclei using the interactive fit routine of ID WIN-NMR. Use the Help information if necessary. 

The methylacarviosin 447, a core structure of acarbose and related pseudo-oligosaccharidic a-amylase inhibitors, together with its 6-hydroxy analog 448, were prepared by Shibata et al. [257] from the corresponding oligobiosaminide derivatives 443 and 444. The aziridine intermediates 445 and 446 were treated with hydrochloric acid to give the corresponding 6 -chloro derivative, and then elimination of the chlorine by base fmnished the title compoimds 447 and 448 as peracetylated derivatives (compoimds 441-448). 

A number of amylase inhibitors have been reported these are proteins, glycoproteins or pseudo-oligosaccharides isolated originally from grains or microorganisms. Acarbose, Bay g 5421 is the most... 

J. M. Garcia Fernandez, C. O. Mellet, V. M. Diaz Perez, J. Fuentes, J. Kovacs, and I. Pinter, Synthesis of (1 -6)-carbodiimide-tethered pseudo oligosaccharides via aza-Wittig reaction, Carbohydr. Res, 304 (1997) 261-270. 

In another nice contribution the sialylation of cyclic pseudo-oligosaccharides, derived by click chemistry, by use of TcTS and MU-Neu5Ac were studied to give di- as well as tri-sialylated products. In all cases a-sialylation was obtained at all terminal Gal-3-positions (Fig. 7) [43]. 

The application of pseudo-3D n.m,r. spectroscopic methods, such as COSY-RELAY, COSY-TOCSY, and RELAY-ROSEY, to oligo- and polysaccharides, has been reptmed. Sequential analy of oligosaccharides can be performed in very short times by use of a modified 3D TOCSY-ROSEY experiment the efficacy of the method has been demonstrated by application to the glycon 26 of verbascosaponin," and a brief explanation of the principles involved has been given. The systematic use of negative nuclear Oveihauser constraints in the determination of oligosaccharide conformations has been applied to sialyl Lewis X. ... 

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